Results 211 to 220 of about 746,982 (336)

Calpain activation is upstream of caspases in radiation-induced apoptosis [PDF]

, 1998
Nigel J. Waterhouse, Debra M Finucane, Douglas R. Green, John S. Elce, Sharad Kumar, Emad S. Alnemri, Gerald Litwack, KumKum Khanna, Martin F. Lavin, Dianne Watters   +9 more
openalex   +1 more source

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

Advanced Science, EarlyView.
Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu   +9 more
wiley   +1 more source

Investigation on antineoplastic potential of Barleria lupulina Lindl: From phytochemical profiling to molecular dynamics simulation assessment. [PDF]

J Ayurveda Integr Med
Banerjee S, Das A, Bose S, Banerjee S, Bishayee A, Bishayee A.   +5 more
europepmc   +1 more source

A Caspase-9 Variant Missing the Catalytic Site Is an Endogenous Inhibitor of Apoptosis [PDF]

, 1999
Dai‐Wu Seol, Timothy R. Billiar
openalex   +1 more source

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

Advanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi, Zejun Gao, Yang Qiu, Renfeng Wang, Keyong Tian, Bo Yue, Xinyu Zhang, Peng Zhang, Ziqi Wu, Qingwen Zhu, Zhenzhen Liu, Zhuoyao Ma, Xueying Zhou, Yu Han, Jun Chen, Jianhua Qiu, DingJun Zha   +16 more
wiley   +1 more source

HOXC8 impacts lung tumorigenesis by preventing pyroptotic cell death through the suppression of caspase-1 expression. [PDF]

Cell Death Dis
Padia R, Sun L, Liao YF, Calbay O, Chi C, Akter M, Wu L, Fu Z, Zhang DD, Huang S.   +9 more
europepmc   +1 more source

Mutant Huntingtin Expression in Clonal Striatal Cells: Dissociation of Inclusion Formation and Neuronal Survival by Caspase Inhibition

, 1999
Manho Kim, H-S Lee, Genevieve Laforet, Charmian McIntyre, Eileen J. Martin, Patrick Chang, Tae Wan Kim, Michael Williams, P. Hemachandra Reddy, Dan Tagle, Frederick M. Boyce, Lisa Won, Alfred Heller, Neil Aronin, Marian DiFiglia   +14 more
openalex   +1 more source

Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance

Advanced Science, EarlyView.
This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian, Jinxiang Wang, Qiji Li, Yangruiyu Liu, Yanping Chen, Jiacheng Feng, Zi‐Ning Lei, Harsh Patel, Chao‐Yun Cai, Yuzhi Xu, Chuntao Quan, Lingyan Fei, Zexiu Xiao, Shuo Fang, Tianxin Lin, Zhe‐Sheng Chen, Yuchen Liu, Leli Zeng, Yihang Pan   +18 more
wiley   +1 more source

Mitigation of sepsis-induced liver injury by Clemastine via modulating GSDMD/NLRP-3/Caspase-1/NF-κB signalling pathways. [PDF]

Eur J Med Res
Abdelnaser M, Attya ME, El-Rehany MA, Fathy M.   +3 more
europepmc   +1 more source

Role of Caspases in N‐Methyl‐d‐Aspartate‐Induced Apoptosis in Cerebrocortical Neurons [PDF]

, 1998
Lalitha Tenneti, Danielle M. D’Emilia, Carol M. Troy, Stuart A. Lipton   +3 more
openalex   +1 more source