Results 211 to 220 of about 526,882 (310)

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

CASVM: web server for SVM-based prediction of caspase substrates cleavage sites

, 2007
Lawrence JK Wee, Tin Wee Tan, Shoba Ranganathan   +2 more
openalex   +2 more sources

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

Journal of Clinical Investigation, 2017
K. Cheng, Shiqin Xiong, Zhiming Ye, Z. Hong, A. Di, K. Tsang, Xiao‐pei Gao, S. An, M. Mittal, S. Vogel, Edward A. Miao, J. Rehman, A. Malik   +12 more
semanticscholar   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Distinct optical and kinetic responses from E/Z isomers of caspase probes with aggregation-induced emission characteristics

, 2014
Jing Liang, Haibin Shi, Ryan T. K. Kwok, Meng Gao, Youyong Yuan, Wen‐Hua Zhang, Ben Zhong Tang, Bin Liu   +7 more
openalex   +2 more sources

Antiproliferative Effect of Okra Seed Protein Isolate against HepG2 and A549 Cell Lines. [PDF]

Chem Biodivers
Maistry L, Gerrano AS, Mellem JJ.
europepmc   +1 more source

Caspase‐3 regulates the migration, invasion and metastasis of colon cancer cells

International Journal of Cancer, 2018
Min Zhou, Xinjian Liu, Zonghai Li, Qian Huang, Fang Li, Chuan-Yuan Li   +5 more
semanticscholar   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

The Role of Pyroptosis in Colorectal Cancer: From Mechanisms to Therapeutic Opportunities. [PDF]

Cancer Manag Res
Xie H, Deng X, Li Q.
europepmc   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source