Results 231 to 240 of about 422,774 (309)

Investigation of Sevoflurane-Induced Apoptotic Damage in Human Cardiomyocytes and the Protective Efficacy of Ascorbic Acid. [PDF]

Medicina (Kaunas)
Aydoğan E, Övey İS, Karahan O.
europepmc   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Thymoquinone protects against statin-induced cerebellar damage, apoptosis, and hepatic cytotoxicity in rats. [PDF]

Sci Rep
Ouies SM, Amin YA, Ragab NA, Ismae ZM, Hassany MA, Abd Elhameed BT, Hassan RGM, Mohammed WI, Abd-El Baki Ahmed M.   +8 more
europepmc   +1 more source

Cell therapy comparison of dental pulp stem cells, hepatocytes, and their exosomes for liver fibrosis treatment in rats

Animal Models and Experimental Medicine, EarlyView.
DPSCs, hepatocytes, and exosomes were tested for liver fibrosis therapy. Exosome‐based treatment exhibited superior antioxidative and regenerative effects. Liver enzymes, oxidative stress, and profibrotic markers were significantly reduced. α‐SMA, desmin, and related gene expression were downregulated.
Sahar Rahimi, Seyedeh Mahdieh Khoshnazar, Ali Derakhshani, Nader Shahrokhi   +3 more
wiley   +1 more source

Unraveling the complexity of pyroptosis in esophageal cancer: from underlying mechanisms to targeted therapies. [PDF]

Cancer Cell Int
Yang W, Wen J, Tang L, Zhan M.
europepmc   +1 more source

Evaluation of cardiac histology and cell death markers during the progression of diabetes in a streptozotocin‐induced diabetes rat model

Animal Models and Experimental Medicine, EarlyView.
Daily insulin administration in streptozotocin‐induced diabetic rats prevented cardiac damage associated with diabetic cardiomyopathy, including hypertrophy, fibrosis, and expression of cell death markers, at 12 weeks. However, cyclophilin D, a marker of mitochondrial permeability transition pore‐opening‐associated cell death (necrosis), was observed ...
Tamara Sáez, Ivo Carrasco‐Wong, Juan Varas, Sebastián San Martín, Jaime A. Riquelme, Rienzi Díaz‐Navarro   +5 more
wiley   +1 more source

Perilipin‐2‐Anchored Lipid Droplet‐Targeting Phototheranostics

Angewandte Chemie, EarlyView.
This study reports two NIR theranostic dyes, C‐BDP‐OH and C‐BDP‐OMe. C‐BDP‐OMe targets lipid droplets via a dual‐anchoring mechanism with PLIN2, enabling wash‐free tumor imaging. With 62.6% photothermal conversion efficiency, it achieves tumor ablation by downregulating PLIN2, disrupting LD‐mitochondria crosstalk, and triggering apoptosis and ...
Lipeng Zhang, Jiyoung Yoo, Juan Bai, Sunghyun Kim, Yesim Bakan, Yongbin Zhang, Fangjun Huo, Jingying Zhou, Caixia Yin, Jong Seung Kim   +9 more
wiley   +2 more sources

Cytotoxic and apoptotic effects of kaempferol 3-O-rhamnoside from Schima wallichii in HepG2 cells. [PDF]

Sci Rep
Lam TMP, Tran MD, Nguyen TK, Le TA, Bich VNT, Truong TT, Pham PTV, Truong HPC, Tran MH.   +8 more
europepmc   +1 more source

Chrysin alleviates pressure overload–induced myocardial remodeling through regulating the PI3K/AKT/NRF2 pathway–mediated oxidative stress response

Animal Models and Experimental Medicine, EarlyView.
In this study, we primarily simulated pathological myocardial remodeling induced by transverse aortic constriction surgery and found significant cardiac hypertrophy and fibrosis, characterized by deteriorated cardiac function. Oxidative stress response is considered as a pivotal pathological process, which contributes to inflammation and apoptosis of ...
Yijia Wang, Xing Feng, Shuhui Zhao, Yuchong Fu, Ao Zhang, Xiaofeng Shen, Bowen Yu, Yihao Wang, Jiahui Lin, Bing Zhang, Weiping Ji, Lianpin Wu, Xiaoling Guo   +12 more
wiley   +1 more source

Mitochondria‐Targeting Moieties Based on N‐Tethered Pyridinium Cations

Angewandte Chemie, EarlyView.
Pyridinium cations were benchmarked as mitochondria‐targeting moieties in a panel of N‐tethered fluorescent‐, bioactive‐, and inert‐cargo conjugates. 3,5‐Diphenylpyridinium (DPPy+) is a competent triphenylphosphonium (TPP+) surrogate, combining high mitochondria‐targeting efficiency with lower intrinsic effects on mitochondrial function.
Ivan Džajić, Natalija Trunkelj, Jernej Repas, Maša Kandušer, Lara Smrdel, Stane Pajk, Lovro Žiberna, Irena Mlinarič‐Raščan, Bostjan Markelc, Tim Bozic, Masa Omerzel, Tanja Jesenko, Maja Cemazar, Katja Kološa, Bojana Žegura, Miha Virant, Matic Lozinšek, Hai M. Nguyen, Joshua A. Nasburg, Heike Wulff, Maxime Gueguinou, Valerije Vrček, Veronica Carpanese, Ildiko Szabo, Luis A. Pardo, Tihomir Tomašič, Lucija Peterlin Mašič, Andrej Emanuel Cotman   +27 more
wiley   +2 more sources