Results 241 to 250 of about 422,774 (309)

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +1 more source

Mitochondria‐Damaging Self‐Reporting Probe for Cancer Therapy

Angewandte Chemie, EarlyView.
We developed a class of self‐reporting cationic chemotherapeutic probes that selectively induce mitochondrial damage and apoptosis in cancer cells. Their unique mitochondria‐to‐nucleus fluorescence migration enables real‐time visualization of the therapeutic process. ABSTRACT Mitochondrial damage induced by chemotherapeutic agents through disruption of
Hai Xu, Yura Lee, Sanghee Yoon, Yun Wang, Yejin Cho, Seongyu Choi, Lu Lu, Hua Zhang, Sun Choi, Ki Taek Nam, Juyoung Yoon   +10 more
wiley   +2 more sources

Angiotensin-(1-7) suppresses pyroptosis in cerebral endothelium to decrease blood-brain barrier permeability and cognitive impairments in sepsis. [PDF]

J Int Med Res
Han Y, Ding H, Chen Y, Wen Y, Zhu H, Su Z, Tang J, Zeng H.   +7 more
europepmc   +1 more source

2‐Azaazulenium Hemicyanine Dyes for NIR‐II Multimodal Imaging and Combined Phototherapy

Angewandte Chemie, EarlyView.
A strategically engineered class of 2‐azaazulenium hemicyanines is developed, featuring bright fluorescence in the second near‐infrared (NIR‐II) window and multifunctional performance. SWJT‐OCH3 shows type I/II reactive oxygen species (ROS) generation and excellent photothermal activity.
Min Peng, Bing‐Ya Wang, Hai Xu, Qiang Wang, Rong‐Dan Xiao, Rui Tan, Yu Peng, Ya‐Wen Wang, Juyoung Yoon   +8 more
wiley   +2 more sources

Cyclodextrin-Based Nanocarriers for 5-Fluorouracil: Cholesteryl Modification Enhances Antitumor Activity Against Colorectal Cancer Cells. [PDF]

Int J Nanomedicine
Skonieczna B, Maliszewski B, Wasiluk N, Car H, Wilczewska AZ, Misiak P, Niemirowicz-Laskowska K.   +6 more
europepmc   +1 more source

Gasdermin D-driven pyroptosis in sepsis: mechanisms, therapeutic strategies, and clinical translation. [PDF]

Front Immunol
Wang Z, Li X, Yuan B, Zhang J.
europepmc   +1 more source

Silencing OTUB1 induces pyroptosis to inhibit the growth of liver cancer HepG2 cells via the NLRP3/caspase/GSDM signaling pathway. [PDF]

J Gastrointest Oncol
Chu WQ, Xu RL, Liu MN, Hu C, Geng XY, Liu J, Lv C, Li Y, Wang J, Wang XH.   +9 more
europepmc   +1 more source

Pyroptosis in epilepsy: from pathophysiological mechanisms to therapeutic strategies. [PDF]

Front Cell Dev Biol
Chen Q, Yang YT, Cai L, Zhang HQ, Yang J.   +4 more
europepmc   +1 more source

[Retracted] Regulation of p38 MAPK phosphorylation inhibits chondrocyte apoptosis in response to heat stress or mechanical stress. [PDF]

Int J Mol Med
Takebe K, Nishiyama T, Hayashi S, Hashimoto S, Fujishiro T, Kanzaki N, Kawakita K, Iwasa K, Kuroda R, Kurosaka M.   +9 more
europepmc   +1 more source

[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models. [PDF]

Mol Med Rep
Liu Y, Zhang Y, Hu M, Li YH, Cao XH.
europepmc   +1 more source