Results 261 to 270 of about 333,383 (311)

Pyroptosis for osteoarthritis treatment: insights into cellular and molecular interactions inflammatory. [PDF]

Front Immunol
Lin M, Zhang C, Li H, Li K, Gou S, He X, Lv C, Gao K.   +7 more
europepmc   +1 more source

Graphene Oxide‐Based Gene Modulation in Preferential Elimination of Lung Cancer Cells in a 3D Tumor Microenvironment Model

Advanced NanoBiomed Research, EarlyView.
Chemically modified graphene oxide nanocarriers provide a targeted lung cancer gene therapy platform. In a 3D tumor microenvironment model, these nanocarriers deliver therapeutic genes, regulate immune markers, and induce apoptosis in cancer cells. Combined gene delivery enhances cancer cell elimination, demonstrating the potential of this approach for
Francesca Grilli, Sadman Sakib, Fabio Variola, Shan Zou   +3 more
wiley   +1 more source

Therapeutic Potential of Emricasan, a Pan-Caspase Inhibitor, in Reducing Cell Death and Extracellular Matrix Accumulation in Fuchs Endothelial Corneal Dystrophy. [PDF]

Cells
Fujimoto S, Endo M, Tonomura S, Tsuji F, Haraguchi H, Hasegawa K, Numao T, Izumi A, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Oyama Y, Ikawa M, Jun AS, Koizumi N, Okumura N.   +15 more
europepmc   +1 more source

Immunoengineering eines Photocage‐geschützten 5′‐Triphosphat‐Oligoribonukleotid‐Liganden zur spatiotemporalen Kontrolle der RIG‐I‐Aktivierung bei Tumoren

Angewandte Chemie, EarlyView.
In dieser Studie wird eine Methode zur präzisen Kontrolle von Retinsäure‐Induzierbaren‐Gens‐I (RIG‐I) vorgestellt, einem Rezeptor des angeborenen Immunsystems, der, wenn er aktiviert wird, antitumorale Immunreaktionen und Zelltod von Krebszellen auslöst.
Sandra Anika Lewash, Vivien Rose McKenney, Christine Wuebben, Janos Ludwig, Racha Hosni, Dirk Radzey, Marieta I. Toma, Eva Bartok, Martin Schlee, Thomas Zillinger, Alexander Heckel, Gunther Hartmann   +11 more
wiley   +1 more source

hsa_circ_0095812 accelerates periodontitis progression by adsorbing miR-485-3p-mediated THBS1 expression. [PDF]

Clinics (Sao Paulo)
Xie X, Li R, Mi F.
europepmc   +1 more source

Immunoengineering of a Photocaged 5´‐triphosphate Oligoribonucleotide Ligand for Spatiotemporal Control of RIG‐I Activation in Cancer

Angewandte Chemie International Edition, EarlyView.
This study presents a method for precise control of RIG‐I (retinoic acid inducible gene I), an innate immune receptor of RNA that, when activated, induces anti‐tumor immune responses and cancer cell death. By incorporating photocage modifications into RNA ligands, we enable a spatially and temporally regulated immune response and offer a targeted ...
Sandra Anika Lewash, Vivien Rose McKenney, Christine Wuebben, Janos Ludwig, Racha Hosni, Dirk Radzey, Marieta I. Toma, Eva Bartok, Martin Schlee, Thomas Zillinger, Alexander Heckel, Gunther Hartmann   +11 more
wiley   +1 more source

Unlocking the power of probiotics, postbiotics: targeting apoptosis for the treatment and prevention of digestive diseases. [PDF]

Front Nutr
Xie Q, Liu J, Yu P, Qiu T, Jiang S, Yu R.   +5 more
europepmc   +1 more source

LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules. [PDF]

Sci Adv
Cao AB, Devant P, Wang C, Sun M, Kennedy SN, Ma W, Ruan J, Kagan JC.   +7 more
europepmc   +1 more source

The Induction and Characterization of a Potential Rough‐Type Brucella Vaccine Candidate Strain RA343, and Its Safety, Protective Efficacy in Mouse and Guinea Pig Models

Animal Research and One Health, EarlyView.
Brucellosis is a zoonotic disease caused by Brucella spp. which seriously jeopardize the health and safety of animals and human beings. In this study, a genetically stable Brucella rough RA343 strain was obtained by cross‐induction. The virulence and protective efficacy of RA343 were subsequently assessed. Overall, the RA343 strain is a promising novel
Linjiao Li, Guangzhi Zhang, Minghe Liu, Lang Lv, Xiaowei Peng, Yu Feng, Xiaotong Yang, Jiabo Ding, Chunhai Liu, Jianhua Qin, Peng Li, Hui Jiang, Xuezheng Fan   +12 more
wiley   +1 more source

Gasdermin E-mediated intestinal epithelial pyroptosis promotes chemically induced colitis in mice. [PDF]

Gastroenterol Rep (Oxf)
Wu YZ, Xie Y, Chen L, Ning L, Hu XQ, Xu XP.   +5 more
europepmc   +1 more source