Advanced Science, EarlyView.This study develops gallium‐doped V2C MXene nanozymes (Ga‐V2C) to treat acetaminophen‐induced liver injury through multi‐death pathway blockade and hepatocyte regeneration. Unlike conventional single‐target therapies like N‐acetylcysteine, Ga‐V2C nanozymes enable oxidative stress suppression, apoptosis, and ferroptosis inhibition, and enhanced ...
Xiaopeng Cai +13 more
wiley +1 more source
Prenyltransferase Inhibitors Induce Apoptosis in Proliferating Thyroid Cells through a p53-Independent, CrmA-Sensitive, and Caspase-3-Like Protease- Dependent Mechanism1 [PDF]
, 1999 Mario Vitale +5 more
openalex +1 more source
Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair [PDF]
, 2020 Hila Israelov +11 more
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DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss
Advanced Science, EarlyView.Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim +11 more
wiley +1 more source
A Caspase-1-cathepsin AND-Gate Probe for Selective Imaging of Inflammasome Activation. [PDF]
ACS Chem BiolChen S +7 more
europepmc +1 more source
Caspase‐1‐Dependent Pyroptosis of Peripheral Blood Mononuclear Cells Is Associated with the Severity and Mortality of Septic Patients [PDF]
, 2020 Yu-Chang Wang +8 more
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Immune Predictors of Radiotherapy Outcomes in Cervical Cancer
Advanced Science, EarlyView.This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang +8 more
wiley +1 more source
Caspase-1 inhibition mitigates neonatal hyperoxia-induced vascular and cardiopulmonary inflammation in neonatal rats. [PDF]
Clin Sci (Lond)León Silva AH +13 more
europepmc +1 more source
Human urine extract CDA-2 induces apoptosis of myelodysplastic syndrome-derived MUTZ-1 cells through the PI3K/Akt signaling pathway in a caspase-3-dependent manner1 [PDF]
, 2008 Jian Huang, Min Yang, Hui Liu, Jie Jin
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Advanced Science, EarlyView.Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang +16 more
wiley +1 more source