Results 141 to 150 of about 17,150,662 (399)
Down-regulation of Survivin enhances sensitivity to BPR0L075 in human cancer cells via caspase-independent mechanisms [PDF]
, 2008 Background: BPR0L075 [6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole] is a novel anti-cancer compound. It inhibits tubulin polymerization and induces mitochondrial-dependent apoptosis in various human cancer cells with different multi-
Chi-Yen Chang +5 more
core +1 more source
Apoptosis in Displaced Temporomandibular Joint Disc with and without Reduction: An Immunohistochemical Study [PDF]
, 2011 Internal derangement (ID) of the temporomandibular joint (TMJ) is due to an abnormal relationship of the articular disc to the mandibular condyle, glenoid fossa and articular eminence.
Almeida, Luis Eduardo +3 more
core +2 more sources
H2O2‐Generating Advanced Nanomaterials for Cancer Treatment
Advanced Functional Materials, EarlyView.H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie +8 more
wiley +1 more source
Sepsis is a syndrome with hyperactivity of TH17-like innate immunity and hypoactivity of adaptive immunity [PDF]
arXiv, 2013 Currently, there are two major theories for the pathogenesis of sepsis: hyperimmune and hypoimmune. Hyperimmune theory suggests that cytokine storm causes the symptoms of sepsis. On the contrary, hypoimmune theory suggests that immunosuppression causes the manifestations of sepsis.
arxiv
Journal of Biological Chemistry, 2015 Background: No reliable treatment exists for cancer-related muscle loss. Results: In muscles of mice with cancer, p-Stat3 stimulates proteolysis by activating caspase-3 and the ubiquitin-proteasome system through a C/EBPδ and myostatin pathway ...
K. Silva +7 more
semanticscholar +1 more source
Cleaved Caspase-3 Sebagai Uji Apoptosis Pada Kanker Serviks IIB Tipe Sel Skuamosa Yang Mendapat Kemoterapi Neoadjuvan Cisplatin [PDF]
, 2015 Tujuan: mencari peningkatan ekspresi cleaved caspase-3 pada pasien kanker serviks IIB tipe sel skuamosa sesudah pemberian kemoterapi neoadjuvan cisplatin dan mencari kapan waktu yang tepat untuk mendeteksi apoptosis menggunakan cleaved caspase-3.
Askandar, B. (Brahmana) +2 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.This study developed a biomimetic scaffold incorporating PDRN and melatonin to restore ovarian function in chemotherapy‐induced premature ovarian insufficiency, enhancing cell survival, folliculogenesis, and hormone normalization, while improving fertility rates and offspring in a mouse model, offering a promising strategy for ovarian function ...
Da‐Seul Kim +8 more
wiley +1 more source
Neurobiology of Disease, 2006 Neonatal hypoxia–ischemia (H–I) is a common cause of perinatal morbidity and mortality leading to prominent activation of caspase-3 in the brain. Previous studies have shown that acute inhibition of caspase-3 can protect against neonatal H–I in rats.
Tim West +2 more
doaj
Antitumor effect of salidroside on mice bearing HepA hepatocellular carcinoma [PDF]
, 2015 Salidroside, a phenylpropanoid glycoside extracted from Rhodiola rosea L., has antiproliferative effects on tumour cells in mice. However it’s antitumor mechanism remains largely unknown. In this study, 4 groups of mice bearing hepatocarcinoma cells were
Dong, Hang +6 more
core
Paracrine control of tissue regeneration and cell proliferation by Caspase-3. [PDF]
, 2013 Executioner caspases such as Caspase-3 and Caspase-7 have long been recognised as the key proteases involved in cell demolition during apoptosis. Caspase activation also modulates signal transduction inside cells, through activation or inactivation of ...
Boland, Karen +2 more
core +1 more source