Results 121 to 130 of about 328,165 (224)

Activation of NF-κB by FADD, Casper, and Caspase-8 [PDF]

, 2000
Wen-Hui Hu, H.L. Johnson, Hong‐Bing Shu   +2 more
openalex   +1 more source

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui, Meng Yang, Chengli Yu, Haidong Zhang, Yuan Gong, Yang Hu, Yue Wang, Qingxin Yuan, An Pan, Jiepin Li, Yaowen Hu, Zecheng Jin, Xuemei Peng, Anyuan Wu, Junwei Wang, Qian Wang, Yinan Zhang, Lihong Hu   +17 more
wiley   +1 more source

HIC1 suppresses Tumor Progression and Enhances CD8+ T Cells Infiltration Through Promoting GSDMD‐induced Pyroptosis in Gastric Cancer

Advanced Science, EarlyView.
These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang, Wenqi Du, Lina Ding, Mengdi Wu, Dongsheng Pei   +4 more
wiley   +1 more source

Phosphorylation of caspase-8 by RSKs via organ-constrained effects controls the sensitivity to TNF-induced death

Cell Death Discovery
Caspase-8 (Casp8) serves as an initiator of apoptosis or a suppressor of necroptosis in context-dependent manner. Members of the p90 RSK family can phosphorylate caspase-8 at threonine-265 (T265), which can inactivate caspase-8 for bypassing caspase-8 ...
Peng He, Tingting Ai, Muzhen Qiao, Zhang-Hua Yang, Jiahuai Han   +4 more
doaj   +1 more source

Intracellular Formation of Synthetic Peptide Nanostructures Causes Mitochondrial Disruption and Cell Death in Tumor Spheroids

Advanced Science, EarlyView.
Synthetic peptide nanostructures, formed within cancer cells in response to glutathione, lead to mitochondrial dysfunction and cell death. The nanostructures significantly damage mitochondrial networks, impair cellular respiration, and induce cell death in both 2D cultures and 3D tumor spheroids.
Sarah Chagri, Konrad Maxeiner, Maria J. S. A. Silva, Lisa Förch, Julian Link, Patrick Roth, Raphael Meyer, Jana Fetzer, Anke Kaltbeitzel, Ingo Lieberwirth, Katharina Landfester, Manfred Wagner, David Y.W. Ng, Tanja Weil   +13 more
wiley   +1 more source

Caspase-8-mediated Intracellular Acidification Precedes Mitochondrial Dysfunction in Somatostatin-induced Apoptosis [PDF]

, 2000
Danni Liu, Giovanni Martino, Muthusamy Thangaraju, Monika Sharma, Fawaz Halwani, Shi‐Hsiang Shen, Yogesh Patel, Coimbatore B. Srikant   +7 more
openalex   +1 more source

Erratum: The absence of caspase-8 in the dopaminergic system leads to mild autism-like behavior

Frontiers in Cell and Developmental Biology, 2022
Frontiers Production Office
doaj   +1 more source

Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo

Neurobiology of Disease, 2003
We have investigated the role of caspase-8 and its mode of activation during apoptosis of adult rat retinal ganglion cells (RGCs) in vivo. Retinal pro-caspase-8 expression was almost completely restricted to RGCs.
J.H Weishaupt, R Diem, P Kermer, S Krajewski, J.C Reed, M Bähr   +5 more
doaj  

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

Apoptosis Induced byStaphylococcus aureusin Epithelial Cells Utilizes a Mechanism Involving Caspases 8 and 3 [PDF]

, 2000
Carla A. Wesson, James R. Deringer, Linda E. Liou, Kenneth W. Bayles, Gregory A. Bohach, William R. Trumble   +5 more
openalex   +1 more source