Results 181 to 190 of about 6,015,666 (337)

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

Advanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni, Chengcheng Yang, Junqi Zhang, Zhou Hang, Ming Zheng, Dengyuan Feng, Qinghuan Shen, Jinxu Miao, Xulin Sun, Li Sun, Baixin Shen, Min Gu, Zijie Wang   +12 more
wiley   +1 more source

Caspase-8 and Tyrosine Kinases: A Dangerous Liaison in Cancer. [PDF]

Cancers (Basel), 2023
Contadini C, Ferri A, Cirotti C, Stupack D, Barilà D.   +4 more
europepmc   +1 more source

Expression of caspases-3, -6 and -8 and their relation to apoptosis in non-small cell lung carcinoma [PDF]

, 2001
Ulla T�rm�nen-N�p�nkangas, Ylermi Soini, Katriina Kahlos, Vuokko L. Kinnula, Paavo P��kk�   +4 more
openalex   +1 more source

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source

RAD51 modulates in nasopharyngeal carcinoma cells by regulating Caspase-8-mediated pyroptosis. [PDF]

Discov Oncol
Xie F, Song J, Tian Y, Zhang X, Chen T, Xu M.   +5 more
europepmc   +1 more source

Geranylgeraniol, an Intermediate Product in Mevalonate Pathway, Induces Apoptotic Cell Death in Human Hepatoma Cells: Death Receptor‐independent Activation of Caspase‐8 with Down‐regulation of Bcl‐xL Expression [PDF]

, 2001
Yoshio Takeda, Kazuhiko Nakao, Keisuke Nakata, Atsushi Kawakami, Hiroaki Ida, Tatsuki Ichikawa, Masaya Shigeno, Yuji Kajiya, Keisuke Hamasaki, Yuji Kato, Katsumi Eguchi   +10 more
openalex   +1 more source

Adducin‐1 Facilitates Influenza Virus Endosomal Trafficking and Uncoating by Regulating Branched Actin Dynamics and Myosin IIB Activity

Advanced Science, EarlyView.
In this study, a novel mechanism is unveiled by which ADD1, acting as a molecular switch, coordinates actin branch dynamics and the transport of endocytic viruses and cargoes. Phosphorylation of ADD1 at Ser726 reduces actin branch density, enhancing endosome fusion and attachment to microtubules.
Meijun Jiang, Jiahui Zou, Yaoming Jin, Chenjun Jiang, Shaoyu Tu, Tong Chen, Jinli Guo, Yanqing Cheng, Meilin Jin, Huanchun Chen, Hongbo Zhou   +10 more
wiley   +1 more source

Caspase-8: Arbitrating Life and Death in the Innate Immune System. [PDF]

Cells
Gupta S, Lopez MA, Ektesabi AM, Tsoporis JN, Vaswani CM, Gandhi SY, Fairn GD, Dos Santos CC, Marshall JC.   +8 more
europepmc   +1 more source

The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity

, 2000
Yunyi Wei, Ted Fox, Steve P. Chambers, JoAnne Sintchak, Joyce T. Coll, Julian M.C. Golec, Lora Swenson, Keith P. Wilson, Paul S. Charifson   +8 more
openalex   +1 more source

Death Receptor Recruitment of Endogenous Caspase-10 and Apoptosis Initiation in the Absence of Caspase-8 [PDF]

, 2001
Frank Kischkel, David A. Lawrence, Antoine Tinel, Heidi Leblanc, Arvind K. Virmani, Peter Schow, Adi F. Gazdar, John Blenis, David Arnott, Avi Ashkenazi   +9 more
openalex   +1 more source