Results 181 to 190 of about 328,165 (224)

Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia

Advanced Science, EarlyView.
A structure‐guided peptide derived from a non‐canonical amino acid library simultaneously targets MCL‐1 and BCL‐xL to overcome apoptotic resistance in acute myeloid leukemia. Fused with a CXCR4‐binding motif, the engineered peptide exhibits selective intracellular delivery and potent in vivo efficacy, offering a promising therapeutic strategy against ...
Zhe Wang, Ruizhi Lai, Xinpei Wang, Xu Chen, Youjian Zhou, Shengbin Li, Xiaohui Qiu, Zekai Zeng, Jianye Yuan, Jinghuan Mao, Zhidong Chen, Junqing Wang   +11 more
wiley   +1 more source

A Dual‐Targeting T6SS DNase Drives Bacterial Antagonism and Eukaryotic Apoptosis via the cGAS‐STING‐TNF Axis

Advanced Science, EarlyView.
The bacterial Type VI secretion system (T6SS) emerges as a sophisticated virulence mechanism, leveraging the dual‐function effector TkeA from Yersinia pseudotuberculosis. TkeA concurrently damages rival bacteria and host cell DNA, triggering the host's cGAS‐STING‐TNF pathway and inducing apoptosis.
Li Song, Lei Xu, Pengfei Zhang, Shuying Li, Yichen Qu, Yixin Zhao, Zhenkun Shi, Ruiqi Ma, Yongdong Li, Yi Chen, Yao Wang, Zhengfan Jiang, Gehong Wei, Xihui Shen   +13 more
wiley   +1 more source

Delayed Transplantation of Neural Stem Cells Improves Initial Graft Survival after Stroke

Advanced Science, EarlyView.
Delayed transplantation of human iPSC‐derived neural progenitor cells (NPCs) enhances graft survival, proliferation, and axonal sprouting after stroke. Using bioluminescence imaging and histology in a mouse model of stroke, it is shown that NPC delivery at 7 days post‐stroke is more effective than acute transplantation, highlighting the importance of ...
Rebecca Z Weber, Nora H Rentsch, Beatriz Achón Buil, Melanie Generali, Lina R. Nih, Christian Tackenberg, Ruslan Rust   +6 more
wiley   +1 more source

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways

Advanced Science, EarlyView.
EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen, Ying Li, Yan Yu, Mingze Cai, Hao Li, Minghe Huang, Guochao Yang, Jiageng Guo, Huailin Wang, Zhihong Song, Wei Shen, Huihui Jiang, Haitao Wu   +12 more
wiley   +1 more source

Caspase-8-mediated BID Cleavage and Release of Mitochondrial Cytochrome c duringN ω-Hydroxy-l-arginine-induced Apoptosis in MDA-MB-468 Cells [PDF]

, 2002
Rajan Singh, Shehla Pervin, Gautam Chaudhuri   +2 more
openalex   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3

, 2001
Thomas Wieder, Frank Eßmann, Aram Prokop, Karin Schmelz, Klaus Schulze‐Osthoff, Rudi Beyaert, Bernd Dörken, Peter T. Daniel   +7 more
openalex   +1 more source

Head Involution Defective (Hid)-triggered Apoptosis Requires Caspase-8 but Not FADD (Fas-associated Death Domain) and Is Regulated by Erk in Mammalian Cells [PDF]

, 2002
Jishy Varghese, Hadassah Sade, Peter Vandenabeele, Apurva Sarin   +3 more
openalex   +1 more source

Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Three PtIV prodrugs MRP, DRP, and HRP are designed to induce pyroptosis in low GSDME‐expressing tumor cells via the Caspase‐3/GSDME pathway. By relaxing chromatin and reactivating GSDME, HRP can effectively induce pyroptosis, enhance pro‐inflammatory cytokine production, and exhibit potent antitumor effects.
Xinda Yang, Chuansheng Xu, Youliang Zeng, Chunhui Wang, Yan Gao, Jie Ding, Sirui Chen, Yuheng Pan, Xin Zhang, Zongwan Mao, Shuo Shi   +10 more
wiley   +1 more source

Mitomycin C induces apoptosis and caspase-8 and -9 processing through a caspase-3 and Fas-independent pathway [PDF]

, 2002
Farzaneh Pirnia, E Schneider, Daniel Betticher, Markus Borner   +3 more
openalex   +1 more source