Results 261 to 270 of about 6,015,666 (337)

Mesoporous Gold Nanospheres Confined Platinum Nanoclusters as Robust ROS and Oxygen Nanogenerators for NIR‐II Hyperthermia Cancer Therapy

Advanced Science, EarlyView.
Mesoporous gold nanospheres confined platinum nanoclusters (MGNSs@Pt) is developed as robust hydroxyl radical and oxygen nanogenerators for multimodal therapies. Their NIR‐II LSPR property also allowed MGSNs to be ideal phototheranostic agents. The chemodynamic and photothermal therapy efficiently induced the tumor cell apoptosis, enabling the MGNSs@Pt
Fei Cun, Jie Chen, Hanxue Li, Yufang Kou, Meiyan Wang, Xiaomin Li, Hui Chen, Jilie Kong   +7 more
wiley   +1 more source

Genetically predicted Caspase 8 levels mediates the causal association between CD4+ T cell and breast cancer. [PDF]

Front Immunol
Chen Y, Zheng Z, Wang J, Huang X, Xie L.
europepmc   +1 more source

Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3

, 2001
Thomas Wieder, Frank Eßmann, Aram Prokop, Karin Schmelz, Klaus Schulze‐Osthoff, Rudi Beyaert, Bernd Dörken, Peter T. Daniel   +7 more
openalex   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

TRIF-TAK1 signaling suppresses caspase-8/3-mediated GSDMD/E activation and pyroptosis in influenza A virus-infected airway epithelial cells. [PDF]

iScience
Sun Y, Yu H, Zhan Z, Liu W, Liu P, Sun J, Zhang P, Wang X, Liu X, Xu X.   +9 more
europepmc   +1 more source

Transforming growth factor beta-induced apoptosis in primary murine hepatocytes is caspase-8 dependent

, 2001
Charles M. Samson, Patty A. Lange, Mark A. Bird, Melissa A. Hayden, David A. Brenner, Kevin E. Behms   +5 more
openalex   +1 more source

Adipocytes Promote Cisplatin Resistance through Secreting A1BG and Regulating NAMPT/PARP1 Axis‐Mediated DNA Repair in Osteosarcoma

Advanced Science, EarlyView.
The proposed working model for how adipocytes participate in cisplatin resistance in osteosarcoma. The adipocytes secret A1BG and stabilize NAMPT, leading to increased NAD⁺ levels and subsequent increased PARP1‐mediated DNA repair, resulting in cisplatin resistance in osteosarcoma finally.
Yonghui Liang, Zhaohui Li, Lina Tang, Zhen Pan, Xiang Fei, Chen Tan, Aina He, Qingcheng Yang, Dongdong Cheng   +8 more
wiley   +1 more source

PARP inhibitors enhance antitumor immune responses by triggering pyroptosis via TNF-caspase 8-GSDMD/E axis in ovarian cancer. [PDF]

J Immunother Cancer
Xia Y, Huang P, Qian YY, Wang Z, Jin N, Li X, Pan W, Wang SY, Jin P, Drokow EK, Li X, Zhang Q, Zhang Z, Li P, Fang Y, Yang XP, Han Z, Gao QL.   +17 more
europepmc   +1 more source

CONVERSION FROM A TYPE I TO A TYPE II DEATH RECEPTOR-MEDIATED PATHWAY THROUGH A PARTIAL INHIBITION OF CASPASE-8

, 2001
Bryan W. Johnson, Enriqué Cepero, Lawrence Boise   +2 more
openalex   +1 more source

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source