Results 261 to 270 of about 459,603 (305)

ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1. [PDF]

Cell Death Differ
Solon M, Ge N, Hambro S, Haller S, Jiang J, Baca M, Preston J, Maltzman A, Wickliffe KE, Liang Y, Reja R, Nickles D, Newton K, Webster JD.   +13 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

From procaspase‐8 to caspase‐8: Revisiting structural functions of caspase‐8

Journal of Cellular Physiology, 2010
AbstractCaspase‐8 is well‐characterized to initiate an apoptotic pathway triggered by the external stimuli. The proximity‐driven model recently has been proposed to interpret the activation mechanism of caspase‐8 in so‐far unprecedent detail, in which dimerization, autocleavage, and inhibitor of caspase‐8 are indispensable. Intriguingly, death effector
Yang, Zhao, Xin, Sui, Hong, Ren
openaire   +2 more sources

Caspase-8 for Outer Harmony

Science Signaling, 2009
Ablation of caspase-8 in keratinocytes activates proliferative and inflammatory responses in the epidermis.
Sollberger, Gabriel, Beer, Hans-Dietmar
openaire   +3 more sources

Caspase-8: The double-edged sword

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2020
Caspase-8 is a cysteine - aspartate specific protease that classically triggers the extrinsic apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like FAS, TRAIL-R and TNF-R. Besides it's roles in triggering death receptor-mediated apoptosis, Caspase-8 has also been implicated in the onsets of anoikis, autophagy and ...
Ranadip, Mandal, Joan Compte, Barrón, Izabela, Kostova, Sven, Becker, Klaus, Strebhardt   +4 more
openaire   +2 more sources

Non-apoptotic functions of caspase-8

Biochemical Pharmacology, 2008
Caspases are a family of aspartate-specific cysteine proteases that have been well characterized for their function in apoptosis signaling. Caspase-8 is implicated as an initiator caspase in death receptor-induced signaling to apoptosis and has been studied most extensively for its role in CD95-induced cell death.
Jonathan, Maelfait, Rudi, Beyaert
openaire   +2 more sources

Interferon-γ induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter

Journal of Pediatric Surgery, 2004
The expression of caspase-8, a cysteine protease that is crucial for the apoptotic cascade, is absent in a high percentage of neuroblastomas, the most frequent extracranial solid tumor of infants and children. Resistance of neuroblastomas to death-receptor (eg, tumor necrosis factor alpha (TNF-alpha) receptor)--mediated apoptosis is thought to be ...
Sunghoon, Kim, Junghee, Kang, B Mark, Evers, Dai H, Chung   +3 more
openaire   +2 more sources

Ripoptosome Analysis by Caspase-8 Coimmunoprecipitation

Cold Spring Harbor Protocols, 2016
The biochemical signaling of cell death pathways is executed at a number of different intracellular and/or membrane-bound high-molecular mass complexes. It is crucial to be able to detect the formation, differences in assembly, and differential composition of such complexes to understand their contribution to the execution phase of apoptotic or ...
Maria, Feoktistova, Peter, Geserick, Martin, Leverkus   +2 more
openaire   +2 more sources

Caspase‐8 Gene Expression in Neuroblastoma

Annals of the New York Academy of Sciences, 2004
Abstract: Neuroblastoma (NB) is a solid tumor of infancy that presents a high rate of spontaneous regression, a phenomenon that likely reflects the activation of an apoptotic/differentiation program. Indeed, the level of expression of molecules involved in the regulation of apoptosis, such as p73 or survivin, is a prognostic factor in NB patients. The
Ida, Casciano, Barbara, Banelli, Michela, Croce, Alessandro, De Ambrosis, Angela, di Vinci, Ilaria, Gelvi, Gabriella, Pagnan, Chiara, Brignole, Giorgio, Allemanni, Silvano, Ferrini, Mirco, Ponzoni, Massimo, Romani   +11 more
openaire   +2 more sources

Anti-inflammatory Functions of Caspase-8

2010
Explorations of the functions of receptors of the TNF/NGF family have led to the discovery of various signaling proteins, many of which were later found to mediate effects of other inducers as well. We now have quite detailed knowledge of the mechanisms and molecular complexes by which some of the signaling proteins mediate these additional effects ...
Akhil, Rajput, Tae-Bong, Kang, Konstantin, Bogdanov, Jin-Chul, Kim, Tehila, Ben-Moshe, Andrew, Kovalenko, David, Wallach   +6 more
openaire   +2 more sources

Two faces of caspase-8

Nature Immunology, 2002
A deficit of caspase-8 should presumably lead to over-activation of lymphocytes. A recent report in Nature from Lenardo's group, however, describes humans with a severe caspase-8 deficiency whose T cells, counter-intuitively, have impaired activation abilities.
Bryan C. Barnhart, Marcus E. Peter
openaire   +1 more source