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The Caspase-8 Modulator c-FLIP
Critical Reviews in Immunology, 2005Death receptors belong to the tumor necrosis factor receptor superfamily and can induce apoptosis through activation of procaspase-8. The cellular FLICE-inhibitory protein (c-FLIP) is able to modulate activation of procaspase-8 and thereby prevents induction of apoptosis mediated by death receptors.
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Caspase 8 and Human Villous Cytotrophoblast Differentiation
Placenta, 2010The fusion of villous cytotrophoblast into the placental syncytium is the quintessential process in maintenance of a healthy pregnancy. Efficient fusion requires a phosphatidylserine (PS)-rich cytotrophoblast surface, expression of fusion proteins, cessation of cell cycling, and rearrangement of cytoskeleton to accommodate membrane joining. Significant
N S, Rote, B-R, Wei, C, Xu, L, Luo
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Science's STKE, 2002
Investigation of two siblings with an autoimmune lymphoproliferative syndrome (ALPS) has resulted in the identification of novel functions for caspase-8. The caspases, a family of cysteine proteases, play a key role in executing apoptosis, a cell suicide process that counters cell proliferation to achieve a homeostatic balance.
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Investigation of two siblings with an autoimmune lymphoproliferative syndrome (ALPS) has resulted in the identification of novel functions for caspase-8. The caspases, a family of cysteine proteases, play a key role in executing apoptosis, a cell suicide process that counters cell proliferation to achieve a homeostatic balance.
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Caspase-3, Caspase-8, and Nuclear Factor-??B Expression in Human Cholesteatoma
Otology & Neurotology, 2006Cholesteatoma is characterized by the accumulation of keratinizing epithelium resulting from the proliferation and differentiation of epithelium. Researchers are presently unraveling the role that apoptosis plays in the disease seen in cholesteatoma epithelium. Caspases play a key role in apoptosis.
Masumichi, Miyao +2 more
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Caspase-8 in cancer biology and therapy
Cancer Letters, 2009Caspase-8 belongs to the caspase family of proteases and plays a key role in the regulation of programmed cell death (apoptosis) during normal development as well as in adult life. Since signaling via the death receptor (extrinsic) pathway critically depends on caspase-8, the disturbance of caspase-8 expression or function may contribute to human ...
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SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation
Signal Transduction and Targeted Therapy, 2020Jun Shen, Shi Zhengli, Peng Zhou
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nature, 2015Nobuhiko Kayagaki +2 more
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