Results 311 to 320 of about 6,015,666 (337)

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.

Science, 1998
Tumor necrosis factor alpha (TNF-alpha) binding to the TNF receptor (TNFR) potentially initiates apoptosis and activates the transcription factor nuclear factor kappa B (NF-kappaB), which suppresses apoptosis by an unknown mechanism. The activation of NF-
C. Y. Wang, M. Mayo, R. Korneluk, D. Goeddel, A. Baldwin   +4 more
semanticscholar   +1 more source

Two faces of caspase-8

Nature Immunology, 2002
A deficit of caspase-8 should presumably lead to over-activation of lymphocytes. A recent report in Nature from Lenardo's group, however, describes humans with a severe caspase-8 deficiency whose T cells, counter-intuitively, have impaired activation abilities.
Bryan C. Barnhart, Marcus E. Peter
openaire   +2 more sources

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency.

Gastroenterology, 2019
Caspase-8 (CASP8) is a protease that initiates apoptosis and regulates inflammation and immune responses. We identified germline mutations in CASP8 in 3 unrelated patients with infant-onset inflammatory bowel disease: 2 patients were homozygous for the ...
Anna S. Lehle, H. Farin, Benjamin Marquardt, Birgitta E. Michels, T. Magg, Yue Li, Yanshan Liu, M. Ghalandary, K. Lammens, Sebastian Hollizeck, M. Rohlfs, F. Hauck, R. Conca, C. Walz, B. Weiss, A. Lev, A. Simon, O. Gross, Moritz M. Gaidt, V. Hornung, H. Clevers, N. Yazbeck, Rima Hanna-Wakim, D. Shouval, N. Warner, R. Somech, A. Muise, S. Snapper, P. Bufler, S. Koletzko, C. Klein, D. Kotlarz   +31 more
semanticscholar   +1 more source

Bone marrow–derived mesenchymal stem cells–derived exosomes prevent oligodendrocyte apoptosis through exosomal miR‐134 by targeting caspase‐8

Journal of Cellular Biochemistry, 2018
Ischemic stroke causes severe brain damage and remains one of the leading causes of morbidity and mortality worldwide. The microRNA‐134 (miR‐134) is involved in regulating the process of ischemia injury in neural cells and brain with ischemia stroke. The
Yilei Xiao, Feng-yang Geng, Guifang Wang, Xueyuan Li, Jianxin Zhu, Weijie Zhu   +5 more
semanticscholar   +1 more source

Non-apoptotic functions of caspase-8

Biochemical Pharmacology, 2008
Caspases are a family of aspartate-specific cysteine proteases that have been well characterized for their function in apoptosis signaling. Caspase-8 is implicated as an initiator caspase in death receptor-induced signaling to apoptosis and has been studied most extensively for its role in CD95-induced cell death.
Rudi Beyaert, Jonathan Maelfait
openaire   +3 more sources

The Caspase-8 Modulator c-FLIP

Critical Reviews in Immunology, 2005
Death receptors belong to the tumor necrosis factor receptor superfamily and can induce apoptosis through activation of procaspase-8. The cellular FLICE-inhibitory protein (c-FLIP) is able to modulate activation of procaspase-8 and thereby prevents induction of apoptosis mediated by death receptors.
openaire   +3 more sources

Caspase‐8 Gene Expression in Neuroblastoma

Annals of the New York Academy of Sciences, 2004
Abstract: Neuroblastoma (NB) is a solid tumor of infancy that presents a high rate of spontaneous regression, a phenomenon that likely reflects the activation of an apoptotic/differentiation program. Indeed, the level of expression of molecules involved in the regulation of apoptosis, such as p73 or survivin, is a prognostic factor in NB patients. The
Ilaria Gelvi, Massimo Romani, Angela Di Vinci, Chiara Brignole, Silvano Ferrini, Ida Casciano, Michela Croce, Gabriella Pagnan, Giorgio Allemanni, Alessandro De Ambrosis, Mirco Ponzoni, Barbara Banelli   +11 more
openaire   +2 more sources

Anti-inflammatory Functions of Caspase-8

2010
Explorations of the functions of receptors of the TNF/NGF family have led to the discovery of various signaling proteins, many of which were later found to mediate effects of other inducers as well. We now have quite detailed knowledge of the mechanisms and molecular complexes by which some of the signaling proteins mediate these additional effects ...
David Wallach, Akhil Rajput, Tehila Ben-Moshe, Tae-Bong Kang, Andrew Kovalenko, Jin-Chul Kim, Konstantin Bogdanov   +6 more
openaire   +3 more sources

Ripoptosome Analysis by Caspase-8 Coimmunoprecipitation

Cold Spring Harbor Protocols, 2016
The biochemical signaling of cell death pathways is executed at a number of different intracellular and/or membrane-bound high-molecular mass complexes. It is crucial to be able to detect the formation, differences in assembly, and differential composition of such complexes to understand their contribution to the execution phase of apoptotic or ...
Maria Feoktistova, Martin Leverkus, Peter Geserick   +2 more
openaire   +3 more sources

Caspases

Current Protocols in Protein Science, 2001
AbstractCaspases are a family of cysteine proteases with a strict specificity for aspartate residues involved in inflammatory process and programmed cell death. This overview unit provides basic information on their structure, enzymatic activity, substrate specificity, activation,inhibition and their implication in pathologies.
Guy S. Salvesen, Jean-Bernard Denault
openaire   +3 more sources