Results 161 to 170 of about 6,274,764 (195)
Some of the next articles are maybe not open access.
Human Pathology, 2012
Caspases are essential initiators and executioners of apoptosis. Changes in their expression may contribute to the development of proliferative disorders such as cancer, by altering the death-proliferation homeostatic balance. The aim of this work was to analyze the expression of a broad panel of caspases at the epithelial level in human prostate ...
Gonzalo, Rodríguez-Berriguete +7 more
openaire +2 more sources
Caspases are essential initiators and executioners of apoptosis. Changes in their expression may contribute to the development of proliferative disorders such as cancer, by altering the death-proliferation homeostatic balance. The aim of this work was to analyze the expression of a broad panel of caspases at the epithelial level in human prostate ...
Gonzalo, Rodríguez-Berriguete +7 more
openaire +2 more sources
Expression of phosphorylated caspase‐9 in gastric carcinomas
APMIS, 2007Alterations of caspases, the main executioners of apoptosis, have been described in human cancers. Caspase‐9 plays a crucial role in the initiation phase of the intrinsic apoptosis pathway. Caspase‐9 is phosphorylated at Thr125 through the mitogen‐activated protein kinase (MAPK) pathway, and this phosphorylation is associated with inhibition of caspase‐
Nam Jin, Yoo +3 more
openaire +2 more sources
Caspase-9 as a therapeutic target for treating cancer
Expert Opinion on Therapeutic Targets, 2014Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms. Its activation is believed to involve homo-dimerization of the monomeric zymogens. It binds to the apoptosome to retain substantial catalytic activity.
Bonglee, Kim +2 more
openaire +2 more sources
The role of caspase‐8, caspase‐9, and apoptosis inducing factor in periodontal disease
Journal of Periodontology, 2018AbstractBackgroundCaspases are key mediators of apoptosis. Caspase‐8 mediates extrinsic, and caspase‐9 initiates the intrinsic pathway of apoptosis. Apoptosis Inducing Factor (AIF), a mitochondrial proapoptotic protein, mediates cell death by a caspase‐independent process.
Kübra, Aral +2 more
openaire +2 more sources
Expression of caspase‐8 and caspase‐9 in rat hippocampus during postnatal development
Microscopy Research and Technique, 2011AbstractThe role of caspases in the regulation of apoptosis of neurons during development is well established. An emerging body of evidence indicates that caspases may also play significant roles which are nonapoptotic. We have demonstrated previously that the executor caspase‐3 exhibited a unique pattern of spatiotemporal expression in the postnatal ...
Li-Rong, Chang +5 more
openaire +2 more sources
Immunohistochemical localization of caspase-3, caspase-9 and Bax in U87 glioblastoma xenografts
Journal of Molecular Histology, 2008Development of new therapies for glioblastoma requires animal models that mimic the biological characteristics of human brain tumors. On the other hand, potential antitumoral effects of a new therapeutic strategy are often established by evaluation of tumor cells apoptosis.
Otilia, Zarnescu +3 more
openaire +2 more sources
Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway
Biochemical and Biophysical Research Communications, 2002C(2)-ceramide, a cell-permeable analog of ceramide, caused cell death in cultured rat cortical neuronal cells. C(2)-ceramide-induced neuronal loss was accompanied by upregulation of caspase-3 activity, measured by cleavage of its fluorogenic substrate Ac-DEVD-AMC.
Vilen A, Movsesyan +4 more
openaire +2 more sources
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
Cell, 2020Rajendra Karki +2 more
exaly
Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis
Immunity, 2020Stéphane Pelletier +2 more
exaly