Results 221 to 230 of about 294,959 (259)

Expression Analysis of caspase-6, caspase-9 and BNIP3 in Prostate Cancer

Tumori Journal, 2010
Aims Altered regulation of cell death is a feature of human cancer. The aim of this study was to explore whether the expression of the proapoptotic proteins caspase-6, caspase-9, and Bcl-2/adenovirus E1B-19kDa-interacting protein3 (BNIP3) is altered in prostate cancers.
Nam Jin Yoo, Min Seob Kim, Sang Wook Park, Seong Il Seo, Sang Yong Song, Ji Youl Lee, Sug Hyung Lee   +6 more
openaire   +2 more sources

Changes in Activities of Caspase-8 and Caspase-9 in Human Cervical Malignancy

International Journal of Gynecological Cancer, 2011
The apoptotic process of programmed cell death and its dysfunctions in a variety of human diseases, including cervical cancer, has become the focus of extensive scientific research. Caspases are considered key factors in the execution of apoptosis, although there are many aspects of their role to be elucidated.
Maria Themistokli, Ekonomopoulou, Evaggelos, Babas, Eleutheria, Mioglou-Kalouptsi, Maria, Malandri, Zafiroula, Iakovidou-Kritsi   +4 more
openaire   +2 more sources

Activation of Caspase-8 and Caspase-9 are Required for PC12 Cells Differentiation

Journal of Immunoassay and Immunochemistry, 2015
Nerve growth factor- (NGF) induced potent activation of caspase-8, and caspase-9 in PC12 cells in a time-dependent manner. Peptide inhibition of caspase activity led to a potent reduction in neurite outgrowth in NGF-treated cells. Although NGF treatment resulted in cell-cycle G0/G1 arrest as detected by FACS cell-cycle analysis, caspase inhibitors ...
Makio, Mogi, Ayami, Kondo
openaire   +2 more sources

Analysis of caspase-3, caspase-8 and caspase-9 enzymatic activities in mouse oocytes and zygotes

Zygote, 2004
The current consensus in the literature is that ovulated oocytes that are not fertilized die by apoptosis, but the details of the proteins involved in the apoptotic pathways have not been elucidated. In this paper we confirm that caspase-3, the executioner of apoptosis, is expressed in mouse oocytes, and show that two initiators of apoptosis, caspase-8
Adrian, Papandile, David, Tyas, Donald M, O'Malley, Carol M, Warner   +3 more
openaire   +2 more sources

Immunoreactivity to caspase-3, caspase-7, caspase-8, and caspase-9 forms is frequently lost in human prostate tumors

Human Pathology, 2012
Caspases are essential initiators and executioners of apoptosis. Changes in their expression may contribute to the development of proliferative disorders such as cancer, by altering the death-proliferation homeostatic balance. The aim of this work was to analyze the expression of a broad panel of caspases at the epithelial level in human prostate ...
Gonzalo, Rodríguez-Berriguete, Laura, Galvis, Benito, Fraile, Fermín R, de Bethencourt, Pilar, Martínez-Onsurbe, Gabriel, Olmedilla, Ricardo, Paniagua, Mar, Royuela   +7 more
openaire   +2 more sources

Caspase-9 as a therapeutic target for treating cancer

Expert Opinion on Therapeutic Targets, 2014
Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms. Its activation is believed to involve homo-dimerization of the monomeric zymogens. It binds to the apoptosome to retain substantial catalytic activity.
Bonglee, Kim, Sanjay K, Srivastava, Sung-Hoon, Kim   +2 more
openaire   +2 more sources

Expression of phosphorylated caspase‐9 in gastric carcinomas

APMIS, 2007
Alterations of caspases, the main executioners of apoptosis, have been described in human cancers. Caspase‐9 plays a crucial role in the initiation phase of the intrinsic apoptosis pathway. Caspase‐9 is phosphorylated at Thr125 through the mitogen‐activated protein kinase (MAPK) pathway, and this phosphorylation is associated with inhibition of caspase‐
Nam Jin, Yoo, Sung Hak, Lee, Eun Goo, Jeong, Sug Hyung, Lee   +3 more
openaire   +2 more sources

The role of caspase‐8, caspase‐9, and apoptosis inducing factor in periodontal disease

Journal of Periodontology, 2018
AbstractBackgroundCaspases are key mediators of apoptosis. Caspase‐8 mediates extrinsic, and caspase‐9 initiates the intrinsic pathway of apoptosis. Apoptosis Inducing Factor (AIF), a mitochondrial proapoptotic protein, mediates cell death by a caspase‐independent process.
Kübra, Aral, Cüneyt Asım, Aral, Yvonne, Kapila   +2 more
openaire   +2 more sources

Expression of caspase‐8 and caspase‐9 in rat hippocampus during postnatal development

Microscopy Research and Technique, 2011
AbstractThe role of caspases in the regulation of apoptosis of neurons during development is well established. An emerging body of evidence indicates that caspases may also play significant roles which are nonapoptotic. We have demonstrated previously that the executor caspase‐3 exhibited a unique pattern of spatiotemporal expression in the postnatal ...
Li-Rong, Chang, Jin-Ping, Liu, Yi-Zhi, Song, Tao, Lu, Gang, Lu, Yan, Wu   +5 more
openaire   +2 more sources

Immunohistochemical localization of caspase-3, caspase-9 and Bax in U87 glioblastoma xenografts

Journal of Molecular Histology, 2008
Development of new therapies for glioblastoma requires animal models that mimic the biological characteristics of human brain tumors. On the other hand, potential antitumoral effects of a new therapeutic strategy are often established by evaluation of tumor cells apoptosis.
Otilia, Zarnescu, Felix Mircea, Brehar, Mihaela, Chivu, Alexandru Vladimir, Ciurea   +3 more
openaire   +2 more sources