Results 91 to 100 of about 36,274 (199)

NRF2/xCT‐Mediated Antioxidant Adaptation Attenuates Apoptosis Induced by ASCT2 Inhibition in Prostate Cancer

Cancer Science, EarlyView.
ASCT2 inhibition induces ROS accumulation and activates NRF2‐dependent xCT upregulation in prostate cancer. This adaptive response partially supports residual cystine acquisition and glutathione synthesis, whereas combined ASCT2 and xCT inhibition disrupts redox compensation and predominantly promotes apoptotic cell death.
Jiaxing Wei, Yasutaka Yamada, Takaaki Tamura, Masahiro Sugiura, Xue Zhao, Meng Ni, Adilan Aierken, Tomokazu Sazuka, Yusuke Imamura, Shinichi Sakamoto   +9 more
wiley   +1 more source

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, EarlyView.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source

Mediator kinase inhibition reverses castration resistance of advanced prostate cancer

The Journal of Clinical Investigation
Mediator kinases CDK19 and CDK8, pleiotropic regulators of transcriptional reprogramming, are differentially regulated by androgen signaling, but both kinases are upregulated in castration-resistant prostate cancer (CRPC).
Jing Li, Thomas A. Hilimire, Yueying Liu, Lili Wang, Jiaxin Liang, Balazs Gyorffy, Vitali Sikirzhytski, Hao Ji, Li Zhang, Chen Cheng, Xiaokai Ding, Kendall R. Kerr, Charles E. Dowling, Alexander A. Chumanevich, Zachary T. Mack, Gary P. Schools, Chang-uk Lim, Leigh Ellis, Xiaolin Zi, Donald C. Porter, Eugenia V. Broude, Campbell McInnes, George Wilding, Michael B. Lilly, Igor B. Roninson, Mengqian Chen   +25 more
doaj   +1 more source

‘Fatherhood Under Suspicion’: The Experiences of Fathers of At‐Risk Children From East Jerusalem Following Out‐of‐Home Placement

Child &Family Social Work, EarlyView.
ABSTRACT Fathers, particularly in conservative patriarchal societies and politically complex contexts, are often underrepresented in research on child protection and out‐of‐home placements. Addressing this significant knowledge gap, this study focuses on Palestinian fathers from East Jerusalem whose young children were removed from their homes by court
Mayis Eissa
wiley   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Early‐stage crystalluria‐associated cystitis in a horse: Diagnostic value of serial urine sediment examination

Equine Veterinary Education, EarlyView.
Summary Calcium carbonate crystals are commonly observed in equine urine; however, crystalluria without urolith formation rarely results in clinically significant disease. A 4‐year‐old Japanese Sport Horse developed recurrent haematuria accompanied by the presence of numerous angular calcium carbonate crystals. Discontinuing the calcium supplementation
R. Sato, S. Imai, A. Yamazaki, T. Miyazaki   +3 more
wiley   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Biochemical profiling and symptomatology of androgen deficiency in males with cluster headache: A prospective case–control study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Cluster headache (CH) has historically been considered a male‐dominated disorder, suggesting a role for androgens in its pathophysiology. We aimed to evaluate hormone profiles and symptoms of androgen deficiency in CH.
Willemijn C. Naber, Roemer B. Brandt, Mariël Leon Morales‐Grooters, Ronald van der Wal, Sjoerd A. A. van den Berg, Jelle J. Goeman, Antoinette Maassen van den Brink, Rolf Fronczek   +7 more
wiley   +1 more source

ZmMS1 coordinates ROS homeostasis, lipid allocation, and male fertility for maize breeding applications

Journal of Integrative Plant Biology, EarlyView.
The redox‐sensitive transcriptional repressor ZmMS1 coordinates reactive oxygen species homeostasis and lipid allocation for pollen exine and anther cuticle formation. Loss or precocious expression of ZmMS1 causes male sterility. Constitutive overexpression induces dwarfism and semi‐sterility. These findings enable flexible maize male‐sterility systems
Quancan Hou, Xueli An, Zhenying Dong, Biao Ma, Suowei Wu, Ke Xie, Ziwen Li, Tingwei Yan, Yilin Jiang, Taotao Zhu, Bin Ma, Lina Zhao, Yan Long, Xiangyuan Wan   +13 more
wiley   +1 more source

Clinical benefit of faecal microbiota transplantation administered via a single retention enema as an adjunctive treatment in dogs with chronic enteropathy: a randomised controlled trial

Journal of Small Animal Practice, EarlyView.
Objectives To evaluate the clinical benefit of faecal microbiota transplantation administered via a single retention enema, as an adjunctive treatment in the management of dogs with chronic enteropathy. Materials and Methods Blinded, randomised controlled trial.
F. Allerton, M. J. Whittle, L. Durkin, C. Prior, M. Trehy, H. Swales, F. Duplan, S. Borgonovi, G. Pinchbeck, I. Gajanayake, M. Dunning, T. Sparks, P. Watson, G. C. A. Amos, K. McCallum, J. Bazelle, A. Kent   +16 more
wiley   +1 more source