Results 161 to 170 of about 36,274 (199)

Characterization and Evaluation of CD24 and NPY as Biomarkers for Metastatic Castration-Resistant Prostate Cancer. [PDF]

Diagnostics (Basel)
McHenry PR, Fakhruddin N, Homer K, Gil da Costa RM, True LD, Morrissey C.   +5 more
europepmc   +1 more source

ROS‐ATM‐CBP axis‐mediated PARP1 lactylation aggravates doxorubicin‐induced cardiotoxicity

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
ROS function as signalling molecules to promote CBP‐mediated PARP1 lactylation in an ATM dependent manner, which induces PARP1 PARylation and ultimate cell apoptosis. CBP and SIRT1 as specific lactyltransferase and delactylase of PARP1. Lactylation of PARP1 depends on the LDHA activity and lactate production.
Wenbin Wang, Yingxian Sun
wiley   +1 more source

Immune-inflammation index as prognostic markers in metastatic castration-resistant prostate cancer: a systematic review and meta-analysis. [PDF]

Front Oncol
Qin Z, Liu R, Jing S, Guo C, Li W.
europepmc   +1 more source

SLC7A5 promotes colorectal cancer liver metastasis by reprogramming tryptophan metabolism through the Kyn/XANA‒AhR axis and reshaping the immune microenvironment

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
SLC7A5‒Kyn/XANA signalling activates AhR to drive EMT and metastatsis. SLC7A5 knockdown enhances macrophage antigen presentation and reverses CD8+ T‐cell exhaustion. SLC7A5 knockdown induces antigen‐driven and IgG‐secreting B‐cell clonal expansion. Combination of SLC7A5 inhibition and anti‐PD‐1 therapy offers clinical targeting.
Yaohao Luo, Lei Li, Shanbao Li, Xinshuai Wang, Zeping He, Fangbin Song, Jun Qin, Jinyan Zhang, Junming Xu   +8 more
wiley   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration-Resistant Prostate Cancer and Immune Evasion. [PDF]

Adv Sci (Weinh)
Zhang C, Cheong TL, Narwade N, Dong D, Deng M, Miao Z, Ding Z, Li W, Lei KMK, Wei GH, Poon TCW, Deng CX, Cheung E.   +12 more
europepmc   +1 more source

The evolving landscape of the Warburg effect in gastric cancer: From molecular mechanisms to targeted therapy

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Hypoxia, oncogenic signaling, transcriptional and epigenetic remodeling, and H. pylori–microbiota interactions drive the Warburg effect in gastric cancer. Enhanced glycolysis and lactate export support biosynthesis, remodel the tumor microenvironment, promote stromal activation and immune suppression, and reveal actionable biomarkers and therapeutic ...
Guanmo Liu, Pan Li, Zizhuo Li, Jie Li, Chenggang Zhang, Yihua Wang, Weiming Kang, Xin Ye   +7 more
wiley   +1 more source

Neutrophil‐based immunotherapy: A metabolic lens on mechanisms and therapeutic implications

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
TAN metabolic reprogramming critically contributes to tumour immune evasion. A 4‑Tier TAN‑MetaC classification framework is proposed, along with an overview of translational opportunities and bottlenecks for TAN metabolism‑targeted immunotherapies. Abstract Background Tumor‐associated neutrophils (TANs) serve as pivotal immune modulators in the tumor ...
Wenchao Xu, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +4 more
wiley   +1 more source

Androgenic effects of 11-oxyandrogens in castration-resistant prostate cancer. [PDF]

BMC Cancer
Lapointe-Belleau A, Rouleau M, Villeneuve L, Descarreaux J, Caron P, Beaudoin C, Uchil A, Simonyan D, Dahmani C, Joly-Beauparlant C, Gélinas V, Droit A, Marcoux N, Castonguay V, Lacombe L, Lévesque É, Guillemette C.   +16 more
europepmc   +1 more source

Tumor‐Responsive PLGA‐SS‐HA Nanoparticles for Zinc Complex Delivery Suppress Prostate Cancer via TR3/FTH1 Pathway

Macromolecular Materials and Engineering, Volume 311, Issue 8, August 2026.
A tumor‐responsive PLGA‐SS‐HA nanoplatform enables glutathione‐triggered delivery of zinc complexes to prostate cancer cells. Enhanced intracellular zinc accumulation induces oxidative stress, mitochondrial dysfunction, and apoptosis through activation of the TR3/FTH1 signaling pathway.
Ding Ma, Sheng Ge, Ruimin Ren, Yongqiang Fu   +3 more
wiley   +1 more source

Case Report: Niraparib-abiraterone in HRR-mutated metastatic castration-resistant prostate cancer: clinical insights from five cases. [PDF]

Front Oncol
Vascotto IA, Catalano M, Venturini J, Calandrelli C, Mancini S, Pratesi L, Izzi M, Mela MM, Rossi V, Francini E, Pillozzi S, Antonuzzo L, Roviello G.   +12 more
europepmc   +1 more source