Results 131 to 140 of about 50,964 (281)

NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth.

PURPOSE: Advanced prostate cancer is invariably fatal, with the androgen receptor (AR) being a major therapeutic target. AR signaling inhibitors have improved overall survival for men with advanced prostate cancer, but treatment resistance is inevitable ...
Bertan, C, Coleman, I, Crespo, M, Jones, K, Sharp, A, Rekowski, J, Chessum, N, Li, D, Swain, A, Carreira, S, de Bono, JS, Roumeliotis, TI, Cheeseman, M, Ning, J, Gurel, B, Neeb, AJ, Jiménez Vacas, J, Gil, VS, Weigl, F, Zeng, W, Choudhary, J, Workman, P, Liodaki, K, Yuan, W, Bhamra, A, Pasqua, E, Banerji, U, Ferreira, A, Nelson, PS, Riisnaes, R, Bogdan, D, Buroni, L, Miranda, S, Tunariu, N, Te Poele, R, Powers, M, Figueiredo, I, Clarke, P, Welti, J, Bernett, I   +39 more
core   +1 more source

Cost-effectiveness analyses and cost analyses in castration-resistant prostate cancer: A systematic review.

PLoS ONE, 2018
BackgroundTreatment of metastatic prostate cancer is associated with high personal and economic burden. Recently, new treatment options for castration-resistant prostate cancer became available with promising survival advantages.
Thomas Grochtdreis, Hans-Helmut König, Alexander Dobruschkin, Gunhild von Amsberg, Judith Dams   +4 more
doaj   +1 more source

Improving image quality in terbium‐161 phantom imaging: Quantitative evaluation of DEW and TEW scatter correction methods

Journal of Applied Clinical Medical Physics, Volume 27, Issue 7, July 2026.
Abstract Background Terbium‐161 (Tb‐161) emits gamma rays and beta radiation, enabling both therapeutic and imaging applications. However, the multiple gamma emissions of 161Tb can affect image quality by increasing the scattering rate during SPECT imaging.
Melek Can, Gamze Çapa Kaya, Gül Gümüşer, Yasemin Parlak   +3 more
wiley   +1 more source

Enzalutamide for the treatment of metastatic castration-resistant prostate cancer

, 2015
Alejo Rodriguez-Vida,1 Myria Galazi,1 Sarah Rudman,1 Simon Chowdhury,1 Cora N Sternberg2 1Medical Oncology Department, Guy’s and St Thomas’ NHS Foundation Trust, London, UK; 2Medical Oncology Department, San Camillo and Forlanini Hospitals ...
Galazi M, Rodriguez-Vida A, Rudman S, Chowdhury S, Sternberg CN   +4 more
core  

Investigating the role of neuroendocrine transdifferentiation in the progression to castration resistant prostate cancer

, 2015
Androgen targeted therapies\ud (ATT) are the most commonly used treatments\ud in prostate cancer (PCa).While\ud these therapies are initially effective, PCa cells are able to activate adaptive response\ud pathways to survive these therapies and\ud ...
Hollier, Brett G., Williams, Elizabeth D., Sweeney, Katrina, Stylianou, Nataly, Nelson, Colleen, Rather, Ellca   +5 more
core   +1 more source

Aggressive variants of prostate cancer : are we ready to apply specific treatment right now?

, 2019
Recently, adoption of novel drugs for systemic treatment of metastatic prostate cancer has led to a striking improvement of response rate and survival in both hormone-sensitive and castration-resistant disease.
Ost, P., Surcel, Cristian, Briganti, Alberto, Valerio, M., Mirvald, Cristian, van den Bergh, R., Kretschmer, A., Valerio, Massimo, Tilki, D., Ploussard, Guillaume, Mirvald, C., Kretschmer, Alexander, van den Bergh, Roderick, Surcel, C., Borgmann, Hendrik, de Visschere, P., Tsaur, I., Heidegger, Isabel, Mathieu, R., Briganti, A., Mathieu, Romain, Gandaglia, Giorgio, De Visschere, Pieter, Heidegger, I., Ploussard, G., Gandaglia, G., Tilki, Derya, Tsaur, Igor, Borgmann, H., Ost, Piet, Ost, PietGE380019993036758020004837230000-0002-2203-4848FBC71966-F0ED-11E1-A9DE-61C894A0A6B4, De Visschere, PieterGE32UZGent0019974248088020023092420000-0002-4842-787785878622-C7A5-11E5-9231-2975B5D1D7B1   +31 more
core   +1 more source

Targeting pre-existing club-like cells in prostate cancer potentiates androgen deprivation therapy

EMBO Molecular Medicine
A critical knowledge gap in prostate cancer research is understanding whether castration-tolerant progenitor-like cells that reside in treatment-naïve tumors play a direct role in therapy resistance and tumor progression.
Manon Baurès, Anne-Sophie Vieira Aleixo, Emeline Pacreau, Aysis Koshy, Vanessa Friedrich, Marc Diedisheim, Martin Raigel, Yichao Hua, Charles Dariane, Florence Boutillon, Lukas Kenner, Jean-Christophe Marine, Gilles Laverny, Daniel Metzger, Florian Rambow, Jacques-Emmanuel Guidotti, Vincent Goffin   +16 more
doaj   +1 more source

Tumour‐macrophage crosstalk initiated by NFIC/METTL3 negative feedback loop via exosomal miR‐194‐5p promotes NSCLC progression

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
NFIC/METTL3 negative feedback loop in NSCLC cells suppresses exosomal miR‐194‐5p via m6A methylation; reduced miR‐194‐5p deepresses ZNF106 in macrophages, promoting M2 polarization and IL‐6 secretion; Macrophage‐derived IL‐6 activates JAK2/STAT3 in NSCLC cells to upregulate METTL3, forming a positive feedback loop.
Shu Fang, Mingyue Hao, Han Meng, Yuhang Jiang, Qiwen Li, Jiao Liang, Xiaolu He, Yi Hu, Linling Zhou, Qianrun Wang, Qiyuan Zhuo, Ji Wu, Kesong Shi   +12 more
wiley   +1 more source

Regulation of the prostate-specific hTGP (TGM4) gene and its potential use for prostate cancer gene therapy [PDF]

, 2011
Prostate cancer is a very important health problem in the UK and worldwide. Available treatments such as radiotherapy, surgery and androgen ablation have failed to significantly increase the life expectancy of prostate cancer patients.
Rivera Gonzalez, Guillermo C
core  

PVT1 lincRNA signals an androgen‐dependent transcriptional activation program of oncogenes in prostate cancer cells

International Journal of Cancer, Volume 159, Issue 1, Page 144-158, 1 July 2026.
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho, Fabio Nunes de Mello, Ana Carolina Tahira, Gabriel Nakanishi Fortes, Agatha Fischer‐Carvalho, Pedro Jardim Poli, Murilo Sena Amaral, Sergio Verjovski‐Almeida   +7 more
wiley   +1 more source