Results 191 to 200 of about 3,811,568 (245)

Androgen receptor reactivation in castration-resistant prostate cancer: mechanisms, epigenetic adaptation, and therapeutic vulnerabilities. [PDF]

Front Oncol
Guo J, Wu K, Ma Z, Guo S, Wang F, Lu L.
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Real-World Outcomes of Olaparib Treatment in Japanese Patients With Metastatic Castration-Resistant Prostate Cancer Harboring BRCA Pathogenic or Likely Pathogenic Variants. [PDF]

Int J Urol
Yasuda Y, Yoshida S, Yonese I, Sano Y, Matsumoto S, Urasaki T, Tamiya T, Tanaka H, Ito M, Miura Y, Numao N, Matsuoka Y, Koga F, Yonese J, Fujii Y.   +14 more
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Real-World Outcomes of [¹⁷⁷Lu]Lu-PSMA-617 in the French Early-Access Program for Patients with Metastatic Castration-Resistant Prostate Cancer. [PDF]

J Nucl Med
Bailly C, Vija L, Somme F, Massard V, Barthélémy P, Giraudet AL, Godbert Y, Fléchon A, Girault S, Abadie-Lacourtoisie S, Viala C, Douillet A, Chêne S, Olivier P, Roubaud G.   +14 more
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Real-World Outcomes of Radium-223 Therapy in Metastatic Castration-Resistant Prostate Cancer: Predictive Value of PSA Doubling Time and Enzalutamide Continuation. [PDF]

Int J Urol
Abe K, Miyazawa Y, Nakazawa S, Onose M, Maeno Y, Tsuji Y, Kanayama A, Ohtsu A, Fujizuka Y, Arai S, Nomura M, Sekine Y, Koike H, Matsui H, Suzuki K.   +14 more
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Steroidogenesis in castration-resistant prostate cancer

Urologic Oncology: Seminars and Original Investigations, 2023
Castration resistance is in part attributable to aberrant activation of androgen receptor (AR) signaling by the intracrine activation of androgen precursors derived from adrenal glands. To overcome this, novel AR pathway inhibitors (ARPIs) that suppress androgen synthesis by CYP17 inhibition or AR activation by antiandrogen effects have been developed.
Masaki Shiota, Satoshi Endo, Leandro Blas, Naohiro Fujimoto, Masatoshi Eto   +4 more
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The hallmarks of castration-resistant prostate cancers

Cancer Treatment Reviews, 2015
Prostate cancer has become a real public health issue in industrialized countries, mainly due to patients' relapse by castration-refractory disease after androgen ablation. Castration-resistant prostate cancer is an incurable and highly aggressive terminal stage of prostate cancer, seriously jeopardizing the patient's quality of life and lifespan.
Maria, Katsogiannou, Hajer, Ziouziou, Sara, Karaki, Claudia, Andrieu, Marie, Henry de Villeneuve, Palma, Rocchi   +5 more
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Overcoming castration resistance in prostate cancer

Current Opinion in Urology, 2012
Recent advances in our understanding of the androgen axis signaling pathway have led to the development of therapeutic strategies to overcome the state of 'castration resistance' in prostate cancer. In this review, we examine the mechanisms of castration resistance, as well as recently reported and ongoing clinical studies, which will further identify ...
Che-Kai, Tsao, Alexander C, Small, Matthew D, Galsky, William K, Oh   +3 more
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Immunotherapy for Castration-Resistant Prostate Cancer

Urologic Clinics of North America, 2012
The improved survival with sipuleucel-T, an autologous antigen-presenting cell-based agent, for the treatment of patients with metastatic asymptomatic and minimally symptomatic castration-resistant prostate cancer supports immunotherapy as a valid approach. Also, multiple novel immunotherapeutic approaches are undergoing vigorous investigation.
Guru, Sonpavde, Philip W, Kantoff
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Castration-Resistant Prostate Cancer

Urologic Clinics of North America, 2017
Men with advanced prostate cancer are typically treated with hormonal therapy, which results in tumor shrinkage. However, tumors relapse and develop into a highly aggressive and lethal form of the disease, termed castration-resistant prostate cancer (CRPC).
Alastair H. Davies, Jennifer L. Bishop, Amina Zoubeidi   +2 more
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