Results 31 to 40 of about 50,964 (281)
Molecular targeting of prostate cancer cells by a triple drug combination down-regulates integrin driven adhesion processes, delays cell cycle progression and interferes with the cdk-cyclin axis [PDF]
, 2011 Background: Single drug use has not achieved satisfactory results in the treatment of prostate cancer, despite application of increasingly widespread targeted therapeutics.Eva Juengel, Hudak, Lukasz, Waaga, Ana Maria da Silva Rosa, Roman A Blaheta, Lukasz Hudak, Blaheta, Roman A., Igor Tsaur, Makarević, Jasmina, Haferkamp, Axel, Jens-Michael Seibel, Wedel, Steffen, Haferkamp Axel, Waaga-Gasser Ana, Seibel Jens-Michael, Juengel Eva, Blaheta Roman A, Makarević Jasmina, Waaga-Gasser, Ana, Jasmina Makarević, Axel Haferkamp, Wedel Steffen, Jüngel, Eva, Seibel, Jens-Michael, Ana Waaga-Gasser, Tsaur Igor, Juengel, Eva, Wedel, Steffen Alexander, Tsaur, Igor, Hudak Lukasz, Steffen Wedel +29 morecore +1 more sourceIdentification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen. [PDF]
PLoS ONE, 2012 As prostate cancer progresses to castration-resistant disease, there is an increase in signal transduction activity. Most castration-resistant prostate tumors continue to express the androgen receptor (AR) as well as androgen-responsive genes, despite ...Hilary Whitworth, Shriti Bhadel, Melissa Ivey, Mark Conaway, Andrea Spencer, Ronald Hernan, Heather Holemon, Daniel Gioeli +7 moredoaj +1 more sourceManagement of patients with advanced prostate cancer—metastatic and/or castration-resistant prostate cancer: report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022 [PDF]
, 2023 Background:
Innovations in imaging and molecular characterisation together with novel treatment options have improved outcomes in advanced prostate cancer. However, we still lack high-level evidence in many areas relevant to making management decisions Yu, EY, Matthew Smith, Jereczek-Fossa, Barbara A., Efstathiou, J, Briganti, Alberto, Merseburger, Axel Stuart Stuart, Yu, Evan Y., Ekeke, O.N., Efstathiou, E, Jereczek-Fossa, Barbara Alicja, Bristow, R.G., Kramer, G., Higano, Celestia S., Higano, C, Dana Rathkopf, Christopher Logothetis, Heinrich, Daniel, Nicholas D. James, Poon, Darren M. C., Ryan, Charles J, Rabah, Danny M, Hussain, M., Sandy Srinivas, Herrmann, K, Pritchard, Colin C., Kramer, G, Morgans, AK, Sartor, O, Davis, I.D., Sade, J.P., Eric Small, Vapiwala, N, Onyeanunam Ngozi Ekeke, Briganti, A., Sade, JP, Valerie Fonteyne, Nguyen, PL, Fizazi, Karim S., Colin C. Pritchard, Clarke, Caroline S., Kramer, Gero, Logothetis, C, Evans, CP, Steuber, T, Sternberg, Cora N., Aparicio, Ana M., Davis, ID, Walz, J., Evan Y. Yu, Hofman, M.S., Murphy, Declan G, Spratt, DE, Efstathiou, J., Rob Jones, Clarke, Noel W., Sharifi, N., Srinivas, S., Beer, T.M., Attard, G, Daugaard, G, Oh, WK, Sharifi, Nima, Inge van Oort, Morgans, Alicia K, Mehra, N, Gillessen, S., Leibowitz, Raya, Padhani, Anwar R, Muhammad Bulbul, Celestia Higano, Davis, Ian D, Dan George, van Oort, I, Hirotsugu Uemura, Jereczek-Fossa, B.A., Bulbul, M., Christopher P. Evans, Mark A. Rubin, Bristow, Rob G, Poon, Ming Chun Darren, Kanesvaran, R, Mahal, B, Kim N. Chi, Maria De Santis, Castro, E., Ost, P., Raja Leibowitz, Mahal, B., Hiroji Uemura, Mottet, N, Efstathiou, Jason, Khauli, R.B., Davis, Ian D., Raja B. Khauli, Elena Castro, Beltran, H, Armstrong, A.J., Horvath, Lisa G., Ana M. Aparicio, Hofman, Michael S, Chi, Kim N., Gedske Daugaard, Gillessen, S, Alicia K. Morgans, Matthew R. Sydes, Rabah, D.M., de Bono, Johann Sebastian, Antonarakis, E.S., Maluf, Fernando Cotait, Saad, Fred, Zapatero, Almudena, Halabi, S., Pezaro, CJ, Susan Halabi, George, D., Mahal, Brandon A., Cora N. Sternberg, O'Sullivan, Joe M; id_orcid, Walz, Jochen, Mukherji, Deborah, Joe M. O’Sullivan, Jones, Robert, Small, E, James, Nicholas D., Omlin, A., Sweeney, Christopher J., Fanti, Stefano, Sharifi, N, Clarke, C.S., Piet Ost, Vedang Murthy, Fossati, Nicola, Bristow, Robert G., Eeles, R., Daniel Castellano, Daniel Heinrich, Declan G. Murphy, Nicolas Mottet, Claire L. Vale, Jones, Rob, Leibowitz, R., Soule, Howard R., Yamoah, K., Eeles, Ros A., Matheson, David, Pierre Blanchard, Carmel J. Pezaro, Feng, Felix Y, Neal Shore, Steuber, T., Merseburger, A., Soule, Howard, Jones, Robert J., Chowdhury, S., van Oort, I., Ürün, Yüksel, van Oort, Inge M., Tombal, B., James, N.D., Vale, Claire L., Small, E., Nguyen, Paul L., Cheng, Heather H., Alberto Briganti, Soule, H, Castellano, D., Higano, Celestia, Maluf, F., O’Sullivan, J.M., De Santis, M, Bossi, Alberto, Beer, Tomasz M., Armstrong, Andrew J., Uemura, H., Frydenberg, Mark, Uemura, Hirotsugu, Silke Gillessen, Taplin, M-E, Tilki, D., Castellano, D, Saad, F, Evans, Christopher P., Aparicio, AM, Efstathiou, Jason Alexander, Mukherji, D., Suzuki, H., Sweeney, Christopher J, Clarke, Noel, Padhani, Anwar R., Emmanuel S. Antonarakis, de Bono, Johann, Skoneczna, Iwona, Ye, Dingwei, Hind Mrabti, O'Sullivan, Joe M, Armstrong, Andrew J, Yamoah, Kosj, Logothetis, Christopher J, Tilki, Derya, Ost, P, Ryan, CJ, Merseburger, Axel, Kellokumpu-Lehtinen, Pirkko-Liisa, Gerhardt Attard, Kellokumpu-Lehtinen, P.L., Caroline S. Clarke, Gravis, G., Gillessen, Silke, Spratt, Daniel E, Jones, R., Ignacio Duran, Skoneczna, I, Mateo, J., Eleni Efstathiou, Castellano, Daniel, Almudena Zapatero, Spratt, D.E., Walz, Jochen Christoph, Eeles, R, Logothetis, Christopher J., Bulbul, M, Logothetis, Christopher, Michael S. Hofman, Turco, F, Cheng, Heather H, Gravis, Gwenaelle, Scher, Howard I, Bristow, RG, Mottet, N., Jason Efstathiou, Johann de Bono, Frydenberg, M., Vapiwala, N., Barbara A. Jereczek-Fossa, Spratt, Daniel E., Eeles, Ross, Sternberg, CN, Alberto Bossi, Pritchard, Colin C, Gwenaelle Gravis, Fernando Maluf, Thomas Steuber, Srinivas, S, Vale, C.L., Bjartell, Anders S., Mary-Ellen Taplin, Shore, Neal, Bjartell, Anders, Darren M.C. Poon, Briganti, A, Castro, Elena, Rubin, Mark A., Niven Mehra, Halabi, Susan, Gleave, M, Leibowitz, Raja, Horvath, Lisa G, Antonarakis, ES, Bertrand Tombal, Bulbul, Muhammad, James, Nicholas D, Fonteyne, V, Yu, E.Y., Christopher J. Sweeney, Smith, Matthew, Nima Sharifi, Mrabti, H., Maluf, Fernando, Ürün, Y, Kellokumpu-Lehtinen, Pirkko Liisa Irmeli, Ross Eeles, Hussain, Maha H.A., Karim Fizazi, James, ND, Small, Eric, Walz, J, Fonteyne, Valerie, Zilli, T., Fabio Turco, Klotz, Laurence, Hussain, Maha, Aparicio, A.M., Chi, Kim N, Tomasz M. Beer, Poon, Darren M C, Rubin, M.A., David Matheson, de Bono, J, Kellokumpu-Lehtinen, PL, Türkeri, Levent N., Taplin, Mary-Ellen, Türkeri, L, Duran, I, Rathkopf, D, Uemura, H, Ekeke, Onyeanunam, Herrmann, Ken, Daugaard, G., Oh, W.K., Hussain, M, Jereczek-Fossa, BA, George, Daniel J., Eeles, Ros, Beltran, Himisha, Ian D. Davis, Simon Chowdhury, Reiter, RE, Ravindran Kanesvaran, Duran, I., Evans, C.P., Omlin, Aurelius, Zapatero, A, Padhani, A.R., Murthy, V., Feng, Felix Y., Maluf, F, Higano, C., Murthy, V, Leibowitz, R, Caffo, O., Mark Frydenberg, Smith, Matthew Raymond, Morris, MJ, Duran, Ignacio, Small, Eric Jay, Mateo, Joaquin, Fossati, N, Fizazi, Karim, Murthy, Vedang, Fonteyne, V., Nicola Fossati, Nguyen, Paul L, Aparicio, Ana M, Tombal, B, Cheng, H.H., Clarke, Caroline S, Howard I. Scher, Mrabti, H, Türkeri, Levent, Clarke, N., Caffo, O, Reiter, Robert E, Shore, N., Sydes, M.R., Turco, Fabio, Klotz, Laurence H., Martin Gleave, Yüksel Ürün, De Santis, M., Khauli, RB, Yamoah, K, Omlin, A, Kosj Yamoah, Srinivas, Sandy, Rathkopf, D., Suzuki, Hiroyoshi, Joaquin Mateo, Antonarakis, Emmanuel S, Khauli, Raja Bahjat, Matheson, D., Sydes, Matthew R, Levent Türkeri, Felix Y. Feng, Klotz, L., Ekeke, Onyeanunam Ngozi, Ost, Piet, Herrmann, K., Cheng, HH, Matheson, D, Khauli, Raja B, van Oort, Inge, Shore, N, Mateo, J, Fizazi, K, Rubin, MA, Padhani, Anwar Roshanali, Horvath, LG, Fanti, S., Kanesvaran, Ravindran, Mahal, Brandon, Thomas Zilli, Türkeri, L., Sartor, Oliver, Feng, F.Y., Vale, Claire L, George, Daniel, Neha Vapiwala, Murphy, D.G., Fanti, S, Sternberg, Cora Nanette, Attard, Gerhardt, Bulbul, Muhammad Ahmad, Beer, TM, Frydenberg, M, Jereczek-Fossa, Barbara A, Uemura, Hiroji, Omlin, Aurelius Gabriel, Bjartell, A., Vale, CL, Howard Soule, Morgans, A.K., Iwona Skoneczna, Beer, Tomasz M, Gravis, G, Turco, F., Pritchard, Colin, Padhani, AR, Fonteyne, Valérie H., Heinrich, D, Michael J. Morris, Hofman, MS, Merseburger, A, Fossati, N., Blanchard, P., Ken Herrmann, Himisha Beltran, Robert E. Reiter, Klotz, L, Mrabti, Hind, Kellokumpu-Lehtinen, P-L, Gillessen Sommer, Silke, Caffo, Orazio, de Bono, J., Daugaard, Gedske, Rabah, DM, Pezaro, Carmel J, Sweeney, Christopher, Axel Merseburger, Zilli, Thomas, Heather H. Cheng, Noel Clarke, O’Sullivan, Joe M., Vapiwala, Neha, Sternberg, Cora N, Soule, H., Ryan, Charles J., Gleave, Martin E., Blanchard, P, Antonarakis, Emmanuel S., Morris, Michael J, Scher, Howard I., Aurelius Omlin, Hiroyoshi Suzuki, Rathkopf, Dana, George, Dan, Chowdhury, Simon, Gleave, Martin, Clarke, CS, Lisa G. Horvath, Oh, William K, O'Sullivan, Joe M., Scher, HI, Pritchard, CC, Sade, Juan Pablo, Jochen Walz, Daniel E. Spratt, Pezaro, C.J., Bjartell, A, Sternberg, C.N., DMC, Poon, Morgans, Alicia K., Brandon Mahal, De Santis, Maria, Murphy, Declan G., Paul L. Nguyen, Clarke, N, Kanesvaran, R., Juan Pablo Sade, Mukherji, Deborah M., Yu, Evan Yi Wen, Rathkopf, Dana E., Tombal, Bertrand, Reiter, Robert E., Morris, Michael J., Pezaro, Carmel J., Danny M. Rabah, Evans, Christopher P, Laurence Klotz, Sartor, Oliver A., Ekeke, ON, Pritchard, C.C., Reiter, R.E., Smith, Mathew, Smith, M, Gero Kramer, Poon, DMC, Smith, M., Attard, G., Dingwei Ye, Beltran, H., Blanchard, Pierre, Efstathiou, Eleni, Scher, H.I., Anders Bjartell, Matheson, David J., Kellokumpu-Lehtinen, Pirkko Liisa, Oliver Sartor, Hofman, Michael S., Skoneczna, Iwona A., de Bono, Johann S., Tombal, B. F., James, Nicholas David, Charles J. Ryan, Jones, R, Sydes, Matthew R., Morgans, Alicia Katherine, Deborah Mukherji, Castellano, Daniel E., O'Sullivan, JM, Ye, D., Gleave, M., Morris, M.J., Shore, Neal D., Mukherji, D, Fizazi, K., Yu, Evan Y, Nguyen, P.L., Maha Hussain, Rabah, Danny M., Suzuki, H, Heinrich, D., Sweeney, C., Mottet, Nicolas, Mehra, N., Halabi, Susan S., Taplin, Mary Ellen, Pirkko-Liisa Kellokumpu-Lehtinen, Murphy, DG, Efstathiou, E., Zapatero, A., Chowdhury, S, Rob G. Bristow, Derya Tilki, Sydes, MR, Horvath, L.G., Tilki, D, Rubin, Mark A, William K. Oh, Ye, D, Skoneczna, I., Orazio Caffo, Poon, Darren M.C., Mahal, Brandon A, Armstrong, AJ, Ürün, Y., Bristow, Rob G., Feng, FY, Mehra, Niven, Logothetis, C., Anwar R. Padhani, Chi, KN, Steuber, Thomas, Stefano Fanti, Chi, K.N., Taplin, M.E., Sartor, O., Ryan, C.J., Zilli, T, Andrew J. Armstrong, Khauli, Raja B., Fred Saad, Castro, E, Halabi, S, Oh, William K., Bossi, A, Rathkopf, Dana E, Saad, F., George, D, Sweeney, CJ +568 morecore +1 more sourceAutocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
Cell Reports, 2023 Summary: The emergence of castration-resistant prostate cancer remains an area of unmet clinical need. We recently identified a subpopulation of normal prostate progenitor cells, characterized by an intrinsic resistance to androgen deprivation and ...Ivana Steiner, Teresita del N.J. Flores-Tellez, Renaud Mevel, Amin Ali, Pengbo Wang, Pieta Schofield, Caron Behan, Nicholas Forsythe, Garry Ashton, Catherine Taylor, Ian G. Mills, Pedro Oliveira, Simon S. McDade, Dietmar M. Zaiss, Ananya Choudhury, Georges Lacaud, Esther Baena +16 moredoaj +1 more sourcePARP inhibition and pharmacological ascorbate demonstrate synergy in castration-resistant prostate cancer. [PDF]
Mol OncolPharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.Gordon N, Gallagher PT, Richter OI, Poudel Neupane N, Mandigo AC, McCann JJ, Dylgjeri E, Vasilevskaya I, McNair C, Paller CJ, Kelly WK, Knudsen KE, Schiewer MJ, Shafi AA. +13 moreeuropepmc +2 more sourcesDarolutamide For Castration-Resistant Prostate Cancer.
OncoTargets and therapy, 2019 The treatment landscape of advanced prostate cancer continues to evolve rapidly, with newer and more active drugs being used in earlier phases of the disease based on improved overall survival. After adoption of docetaxel for metastatic castration-sensitive disease, large trials with next-generation androgen receptor-signaling inhibitors (abiraterone ...Bastos,Diogo A, Antonarakis,Emmanuel Sopenaire +3 more sourcesSingle-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer
Cell Reports, 2018 Summary: The exact identity of castrate-resistant (CR) cells and their relation to CR prostate cancer (CRPC) is unresolved. We use single-cell gene profiling to analyze the molecular heterogeneity in basal and luminal compartments.João D. Barros-Silva, Douglas E. Linn, Ivana Steiner, Guoji Guo, Adnan Ali, Hubert Pakula, Garry Ashton, Isabel Peset, Michael Brown, Noel W. Clarke, Roderick T. Bronson, Guo-Cheng Yuan, Stuart H. Orkin, Zhe Li, Esther Baena +14 moredoaj +1 more source
