Results 71 to 80 of about 50,964 (281)

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Control of gene expression in prostate epithelial cell differentiation hierarchy [PDF]

, 2012
The aim of present investigation is to elucidate the complex stem cell (SC) dynamics within prostate cancer, which can be exploited to design novel diagnostic and therapeutic strategies for the management of prostate cancer.
Rane, Jayant
core  

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Pharmacotherapeutic strategies for castrate-resistant prostate cancer

Expert Opinion on Pharmacotherapy, 2020
Metastatic castration-resistant prostate cancer (CRPC) is a potentially symptomatic disease with an eventual lethal outcome. Novel pharmaceutical agents are continuously studied with encouraging results in CRPC.In this perspective, the authors present established and promising pharmacotherapeutic strategies for the management of CRPC; both with and ...
Moussa, M., Papatsoris, A., Abou Chakra, M., Sryropoulou, D., Dellis, A.   +4 more
openaire   +3 more sources

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Survival after spinal surgery for metastases in men with castration-sensitive vs castration-resistant prostate cancer: a nationwide register-based study

Scientific Reports
This nationwide register-based cohort study examined the association between castration status and postoperative survival in men who had undergone surgery for spinal metastases from prostate cancer. Bone metastases are common in prostate cancer, with the
Johan Wänman, Mehdy Farhang, Helena Nyström, Johan Styrke, Christel Häggström, Pär Stattin, Sead Crnalic   +6 more
doaj   +1 more source

Dissecting the roles of the androgen receptor in prostate cancer from molecular perspectives

Tumor Biology, 2017
Androgen receptor plays a pivotal role in prostate cancer progression, and androgen deprivation therapy to intercept androgen receptor signal pathway is an indispensable treatment for most advanced prostate cancer patients to delay cancer progression ...
Jieping Hu, Gongxian Wang, Ting Sun
doaj   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer

, 2022
Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g.
Robinson, Brian D., Rutland, Catrin S., Martin, Laura M.,, Varun, Dhruvika,, Allegrucci, Cinzia, Toss, Michael S., Haque, Maria,, Ntekim, Atara,, Endeley, Chantelle,, Rakha, Emad,, Metzler, Veronika M., Mongan, Nigel P, James, Victoria H., Harris, Anna E., Haigh, Daisy B, Mongan, Nigel P.,, Harris, Anna E, Persson, Jenny L, Haigh, Daisy B.,, James, Victoria H.,, Toss, Michael S, Gudas, Lorraine J, Mongan, Nigel P., de Brot, Simone,, Toss, Michael S.,, Ntekim, Atara, Robinson, Brian D.,, Persson, Jenny L., Martin, Laura M., Varun, Dhruvika, Brownlie, Juliette, Martin, Laura M, Rutland, Catrin S, Fray, Rupert G, Rakha, Emad, Woodcock, Corinne L, Moyer, Jenna E, Jeyapalan, Jennie N, Alsaleem, Mansour, Moyer, Jenna E., Jeyapalan, Jennie N., Harris, Anna E.,, Allegrucci, Cinzia,, Fray, Rupert G.,, Rutland, Catrin S.,, Metzler, Veronika M, Endeley, Chantelle, Gudas, Lorraine J.,, Metzler, Veronika M.,, Haque, Maria, Lothion-Roy, Jennifer,, Persson, Jenny L.,, Woodcock, Corinne L., Jeyapalan, Jennie N.,, Haigh, Daisy B., Madhusudan, Srinivasan, Madhusudan, Srinivasan,, James, Victoria H, Woodcock, Corinne L.,, Gudas, Lorraine J., Fray, Rupert G., Lothion-Roy, Jennifer, Moyer, Jenna E.,, Brownlie, Juliette,, de Brot, Simone, Khani, Francesca, Robinson, Brian D, Khani, Francesca,, Alsaleem, Mansour,   +68 more
core   +1 more source