Results 151 to 160 of about 86,006 (297)

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

NRF2/xCT‐Mediated Antioxidant Adaptation Attenuates Apoptosis Induced by ASCT2 Inhibition in Prostate Cancer

Cancer Science, EarlyView.
ASCT2 inhibition induces ROS accumulation and activates NRF2‐dependent xCT upregulation in prostate cancer. This adaptive response partially supports residual cystine acquisition and glutathione synthesis, whereas combined ASCT2 and xCT inhibition disrupts redox compensation and predominantly promotes apoptotic cell death.
Jiaxing Wei, Yasutaka Yamada, Takaaki Tamura, Masahiro Sugiura, Xue Zhao, Meng Ni, Adilan Aierken, Tomokazu Sazuka, Yusuke Imamura, Shinichi Sakamoto   +9 more
wiley   +1 more source

Self-castration [PDF]

BMJ, 1949
openaire   +2 more sources

La castration : une arme féminine ?

La castration : une arme féminine ? Ami NagaiDoctorante en histoire contemporaine, Temps, espaces, langages Europe méridionale-Méditerranée, Aix-Marseille Université Cette communication a été consacrée au crime de castration considéré comme un mode de ...
mshbordeaux
core   +1 more source

‘Fatherhood Under Suspicion’: The Experiences of Fathers of At‐Risk Children From East Jerusalem Following Out‐of‐Home Placement

Child &Family Social Work, EarlyView.
ABSTRACT Fathers, particularly in conservative patriarchal societies and politically complex contexts, are often underrepresented in research on child protection and out‐of‐home placements. Addressing this significant knowledge gap, this study focuses on Palestinian fathers from East Jerusalem whose young children were removed from their homes by court
Mayis Eissa
wiley   +1 more source

Reprogramming the Evolution of High-Risk Prostate Cancer: Multidisciplinary Strategies to Delay Castration Resistance. [PDF]

J Clin Med
Sim Y, Choi JW, Kim DS, Kim JH, Yoon SG, Jo JK.   +5 more
europepmc   +1 more source

Testicular torsion in foals and stallions

Equine Veterinary Education, EarlyView.
Summary Testicular torsion is a rare condition in horses characterised by a change in the position of the testis due to the testicular mesentery twisting around its own axis; it can occur both when the testis is still in the abdominal cavity and when it has descended into the scrotum.
C. P. Bartmann
wiley   +1 more source

Real-World Outcomes of Olaparib in Japanese Patients With BRCA-Mutated Metastatic Castration-Resistant Prostate Cancer: Exploratory Analysis of BRCA2 Loss and Microsatellite Instability Status. [PDF]

Int J Urol
Nukaya T, Naiki T, Watanabe H, Nakane K, Inamoto T, Yasui T, Koie T, Takahara K.   +7 more
europepmc   +1 more source

Surgical castration in large dogs: is closed castration safer than open? [PDF]

Vet Evid
Morrison F.
europepmc   +1 more source

A retrospective analysis of bacterial pathogens in wounds in an equine hospital (2017–2022)

Equine Veterinary Education, EarlyView.
Summary Background Bacterial infections are a major cause of morbidity in horses, particularly in soft tissue wounds (STW) and surgical site infections (SSI). Rising antimicrobial resistance poses challenges for timely treatment. Knowledge of common pathogens and their resistance patterns is therefore essential.
J. Nebes, M. Schneeberger, S. Schmitt, J. N. van Spijk   +3 more
wiley   +1 more source