Results 171 to 180 of about 219,417 (396)
Cancer Research, 2017 Resistance invariably develops to antiandrogen therapies used to treat newly diagnosed prostate cancers, but effective treatments for castration-resistant disease remain elusive.
Lingyan Jin +17 more
semanticscholar +1 more source
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, EarlyView.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
THE URINARY EXCRETION OF ESTROGENS, ANDROGENS AND FSH FOLLOWING THE ADMINISTRATION OF TESTOSTERONE TO HUMAN FEMALE CASTRATES [PDF]
, 1939 Ira T. Nathanson +2 more
openalex +1 more source
Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture
International Journal of Cancer, EarlyView.Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert +3 more
wiley +1 more source
Castration for Uterine Fibroids [PDF]
The American Journal of the Medical Sciences, 1902 n ...
openaire +2 more sources
CASTRATION FOR TUBERCULOSIS OP THE TESTICLE.1 [PDF]
, 1904 Charles Greene Cumston
openalex +1 more source
Sociocultural determinants of mental health among male sexual trauma survivors
Journal of Traumatic Stress, EarlyView.Abstract Male sexual trauma survivors are understudied compared to their female counterparts despite having a high risk for mental health difficulties. This study aimed to use structural equation modeling to examine the unique influences of sociocultural factors, specifically masculinity facets and negative social reactions upon disclosing sexual ...
Faith O. Nomamiukor, Blair E. Wisco
wiley +1 more source
PR-NET: Leveraging Pathway Refined Network Structures for Prostate Cancer Patient Condition Prediction [PDF]
arXivThe diagnosis and monitoring of Castrate Resistant Prostate Cancer (CRPC) are crucial for cancer patients, but the current models (such as P-NET) have limitations in terms of parameter count, generalization, and cost. To address the issue, we develop a more accurate and efficient Prostate Cancer patient condition prediction model, named PR-NET.
arxiv