Results 111 to 120 of about 52,178 (271)

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Amphiregulin and Epiregulin Confer Radioresistance in Esophageal Squamous Cell Carcinoma Through Oxidative Phosphorylation

Advanced Science, EarlyView.
Oxidative phosphorylation (OXPHOS) activity serves as a critical metabolic determinant of radiotherapy outcomes in esophageal squamous cell carcinoma (ESCC). The CEBPB/AREG/EREG axis drives radioresistance in ESCC by reprogramming OXPHOS. AREG and EREG function as predictive biomarkers for nCRT response and prognosis of ESCC patients.
Zhang Lin, Meilian Yao, Xin Xu, Dong Zhang, Lei Xu, Ling Rong, Xiaohang Wang, Yi Duan, Chengkun Chen, Jun Gu, Yao Zhang, Qiang Liu, Qing Ye, Gaoping Cui, Yujun Hao, Xiumei Ma   +15 more
wiley   +1 more source

Cat or Dog Ownership and Seroprevalence of Ehrlichiosis, Q Fever, and Cat-Scratch Disease [PDF]

, 2003
Martina Skerget, Christoph Wenisch, Florian Daxboeck, Robert Krause, Renate Haberl, D Stuenzner   +5 more
openalex   +1 more source

CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation

Advanced Science, EarlyView.
Cell proliferation requires the integration of cell cycle and anabolic signals. G1‐phase regulator CDH1 coordinates anabolism through the CDH1‐VHL‐AARS2/HIF1α axis, while CDH1‐accumulated R5P is sensed by TKTL1 to facilitate CDH1 degradation and cell cycle initiation, constituting a CDH1‐centered regulatory circuit.
Yun‐Zi Mao, Jiao‐Jiao Zhang, Meng‐Qi You, Han Wang, Yan Lin, Yuan Fang, Hui‐Lu Zhang, Yuan‐Yuan Qu, Qian Zhou, Meng Wang, Gang Li, Zi‐Fan Guo, Meng Xu, Jie Liu, Peng‐Cheng Lin, Yi‐Yuan Yuan, Yu Kang, Shi‐Min Zhao, Wei Xu   +18 more
wiley   +1 more source

Cat-scratch disease presenting as a solitary splenic abscess in an elderly man [PDF]

, 2015
Momoko Nakamura, Mio Kurimoto, Takehiro Kato, Takeshige Kunieda   +3 more
openalex   +1 more source

Synergistic Promotion of Triple‐Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella‐Derived Glutamate and Platelet Activation

Advanced Science, EarlyView.
Polystyrene nanoplastics (PS‐NPs) administered via oral exposure accelerate triple‐negative breast cancer (TNBC) progression by synergistically modulating gut microbiota‐derived glutamate production and platelet activation. This study uncovers a pivotal crosstalk between microbial metabolites and platelet‐tumor interactions, offering mechanistic ...
Leilei Zhu, Peihao Xu, Mingyuan Zhou, Kewei Li, Shasha Tian, Xuemei Fan, Junling Liu, Baodong Ye, Zhishan Ding, Yingzhi Shen   +9 more
wiley   +1 more source

Astragaloside II promotes intestinal epithelial repair by enhancing L-arginine uptake and activating the mTOR pathway

, 2017
Astragaloside II (AS II) extracted from Astragalus membranaceus has been reported to promote tissue wound repair. However, the effect of AS II on inflammatory bowel disease is unknown.
Ahmetaj-Shala, B, Chang, T-C, Chang, W-L, Huang, S-F, Lee, S-Y, Lin, J-C, Tsai, W-C   +6 more
core   +2 more sources

Single‐Cell Metabolic Imaging Reveals Glycogen‐Driven Adaptations in Endothelial Cells

Advanced Science, EarlyView.
Single‐cell metabolic imaging of diabetes‐associated endothelial dysfunction by SRS microscopy reveals dynamic glycogen storage and its role in modulating metabolic adaptations under glucose starvation. Abstract Endothelial dysfunction (ED) is a defining feature of diabetes mellitus (DM) and a key contributor to many metabolic and cardiovascular ...
Rahuljeet S. Chadha, Benjamin Yang, Dongqiang Yuan, Edmund D. Kapelczak, Philip A. Kocheril, Alonso Tapia, Shivansh Mahajan, Adrian Colazo, Naseeb K. Malhi, Joseph A. Ambarian, Xuejing Liu, Tara A. TeSlaa, Zhen B. Chen, Lu Wei   +13 more
wiley   +1 more source

Atypical Presentation of Cat-Scratch Disease in an Immunocompetent Child with Serological and Pathological Evidence [PDF]

, 2014
Serkan Atıcı, Eda Kepenekli, Ayşe Karaaslan, Muhammed Hasan Toper, Çiğdem Çelikel, Ahmet Soysal, Mustafa Bakır   +6 more
openalex   +1 more source

NIR‐II Responsive Multifunctional Scaffold Enabling “Kill‐Modulation‐Build” Synergistic Therapy for Infectious Bone Defects

Advanced Science, EarlyView.
A novel multifunctional scaffold with photothermal effects is developed for infected bone defect repair. It facilitates angiogenesis and osteogenesis while eliminating bacteria through hyperthermia. Additionally, the scaffold promotes macrophage polarization from M1 to M2 via ROS scavenging, enhancing anti‐inflammatory activity. This study demonstrates
Qifei Yang, Shu Lou, Yuan Zhang, Zhurun Fang, Changyue Xing, Wentao Wang, Minxuan Han, Zhendong Wang, Ben Zhong Tang, Ming Zhang   +9 more
wiley   +1 more source