Results 121 to 130 of about 36,967 (163)

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

Bridging lab and industry: The impact of a bio‐conversion unit on black soldier fly larvae production and microbiome dynamics

JSFA reports, EarlyView.
Abstract Background This study evaluates the viability of a novel bio‐conversion unit (BCU) for extensive black soldier fly larvae (BSFL) production as a sustainable feed additive for livestock. The BCU's effectiveness in converting organic byproducts into valuable biomass via the production of BSFL was assessed to reduce reliance on environmentally ...
William J. S. Edwards, Chloe Skingle, Richard Small, Robert Barker, Anastasios D. Tsaousis   +4 more
wiley   +1 more source

Major Ozonated Autoheamotherapy Alleviates Skeletal Muscle Ischemia/Reperfusion Injury by Regulating Nrf2/HO‐1 Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Skeletal muscle ischaemia/reperfusion (I/R) injury remains a clinically significant condition characterized by muscular dystrophy. Although ozone therapy has shown protective potential against I/R injury in animal models of various organs including skeletal muscle, its precise mechanistic underpinnings require further elucidation.
Hui‐Zhuang Guo, Sheng‐Long Yu, Han‐Wei Chen   +2 more
wiley   +1 more source

Effects of a high‐fat diet on gut microbiota and possible implications for bone health in male Wistar rats

Lipids, EarlyView.
Abstract Diet plays an important role in the composition of gut microbiota. Emerging research suggests that bone homeostasis can also be influenced by the gut microbiota. The aim of this study was to assess possible alterations in gut microbiota in an experimental obesity model induced by a high‐fat diet (HFD) and the possible effects on parameters of ...
Fernanda Guedes Rodrigues, Milene Subtil Ormanji, Renata Meca, Horácio Montenegro, Lilian Cuppari, Martin H. de Borst, Ita Pfeferman Heilberg   +6 more
wiley   +1 more source

Fabrication of Carbon Nanodots/Platinum Functionalized Nanocomposite Hydrogel Formulation for Near‐Infrared Responsive Delivery of Doxorubicin to Promote Necroptosis for Mitigating Lung Cancer Cells: In Vitro Photodynamic Therapy

Macromolecular Materials and Engineering, EarlyView.
Representation of fabrication of carbon nanodots/platinum functionalized nanocomposite hydrogel formulation for near‐infrared responsive delivery of doxorubicin for lung cancer treatment. Abstract Lung cancer remains one of the deadliest cancers, marked by uncontrolled cell growth in the lungs and often diagnosed at later stages.
Xiaoqin An, Junjun Bai, Yuan Li
wiley   +1 more source

Bioelectronic Hydrogels: Exemplifying the Synergy Between Biopolymers and Conjugated Polymers

Macromolecular Materials and Engineering, EarlyView.
This review aims to highlight the benefits of biopolymer‐based conductive hydrogels as soft bioelectronics for biointerface applications. Biopolymers deliver biocompatibility, commercial availability, low cost, and sustainability, whereas conjugated polymers provide electronic conductivity.
Thanh Nhi Tra, Kristina Fidanovski, Damia Mawad   +2 more
wiley   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Optimized Dynamic Network Biomarker Deciphers a High‐Resolution Heterogeneity Within Thyroid Cancer Molecular Subtypes

Med Research, EarlyView.
An optimized dynamic network biomarker approach reveals a critical transition signal and identifies three distinct molecular subtypes of differentiated thyroid cancer, each with unique global regulatory landscapes. ABSTRACT The progression of differentiated thyroid carcinoma (DTC) poses significant clinical challenges, especially in determining the ...
Haonan Zhang, Ge Zhang, Pengyuan Xu, Fengyi Yu, Liwen Li, Runzhi Huang, Pengpeng Zhang, Kaisaierjiang Kadier, Yuanyuan Wang, Qiqi Gu, Yalei Ding, Tianshu Gu, Hao Chi, Shiqian Zhang, Ruhao Wu, Yudi Xu, Shanshan Zhu, Honglin Zheng, Taiqi Zhao, Qi He, Xinguang Qiu   +20 more
wiley   +1 more source

Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN II) Urinary Urgency Phenotyping Study: Methods and Baseline Urinary Symptoms by Age and Sex

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims To present the methods and baseline findings from a prospective, longitudinal cohort study of treatment seeking adults with urinary urgency (URG) with or without urgency urinary incontinence (UUI). Methods Adults seeking treatment for URG and/or UUI and controls were enrolled.
Giulia M. Ippolito, Kimberly Kenton, Catherine S. Bradley, Ting Lu, Brian Bieber, J. Quentin Clemens, Anna C. Kirby, Ziya Kirkali, Magaly Guerrero, Claire C. Yang, Karl Kreder, C. Emi Bretschneider, John Graff, Julia Nashif, James W. Griffith, H. Henry Lai, Cindy L. Amundsen, Anne P. Cameron, for the LURN Study Group   +18 more
wiley   +1 more source

Cystathionine gamma‐lyase‐mediated hypoxia inducible factor 1‐alpha expression drives clear cell ovarian cancer progression

The Journal of Pathology, EarlyView.
Abstract Clear cell ovarian cancer (CCOC) is the second most common ovarian cancer subtype, accounting for 5%–11% of ovarian cancers in North America. Late‐stage CCOC is associated with a worse prognosis compared to other ovarian cancer histotypes, a challenge that has seen limited progress in recent decades.
Amal M EL‐Naggar, Yuqin Li, Busra Turgu, Yuchen Ding, Longyijie Wei, Shary Yuting Chen, Genny Trigo‐Gonzalez, Forouh Kalantari, Rodrigo Vallejos, Branden Lynch, Janine Senz, Amy Lum, J Maxwell Douglas, Clara Salamanca, Shelby Thornton, Yimei Qin, Kiran Parmar, Sandra E Spencer, Samuel Leung, Michelle MM Woo, Paul J Yong, Hai‐Feng Zhang, Christopher S Hughes, Gian Luca Negri, Yemin Wang, Gregg B Morin, Poul H Sorensen, David G Huntsman   +27 more
wiley   +1 more source