Results 41 to 50 of about 1,039,561 (316)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Part 2: A Sector-Wide Survey of UK/British Isles Shelter Organisations Caring for Cats: Caregiver-Reported Approaches to Assessments, Behaviour Management and Homing Decisions

Veterinary Sciences
Shelter organisations take responsibility for the care, assessment and homing of large numbers of domestic cats from diverse backgrounds. However, not all cats that come under shelter care are suited to close human-cohabitation or to certain types of ...
Lauren R. Finka, Ana M. Barcelos, James Waterman, Avni Bhatia, Jenni L. McDonald, Rae Foreman-Worsley, Beth Skillings   +6 more
doaj   +1 more source

Using Twitter to Infer User Satisfaction With Public Transport: The Case of Santiago, Chile

IEEE Access, 2019
User satisfaction is an important aspect to consider in any public transport system, and as such, regular and sound measurements of its levels are fundamental. However, typical evaluation schemes involve costly and time-consuming surveys.
Jose Tomas Mendez, Hans Lobel, Denis Parra, Juan Carlos Herrera   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Part 1: A Sector-Wide Survey of UK/British Isles Shelter Organisations Caring for Cats: Caregiver-Reported Approaches to Housing, Husbandry and General Care Provision

Veterinary Sciences
Meeting the physiological and psychological needs of shelter cats through appropriate care is critical to reducing stress and disease risk, as well as enabling positive homing outcomes. Shelter organisations across the British Isles provide care for many
Lauren R. Finka, Ana M. Barcelos, James Waterman, Avni Bhatia, Jenni L. McDonald, Rae Foreman-Worsley, Beth Skillings   +6 more
doaj   +1 more source

Fast and Lightweight Object Detection Network: Detection and Recognition on Resource Constrained Devices

IEEE Access, 2018
The intrinsic ability of humans to rapidly detect, differentiate, and classify objects allows us to make quick decisions in regards to what we see. Several appliances can make use of fast and lightweight automated object detection for images or videos ...
Bernardo Augusto Godinho de Oliveira, Flavia Magalhaes Freitas Ferreira, Carlos Augusto Paiva da Silva Martins   +2 more
doaj   +1 more source

Behavioral differences among domestic cats in the response to cat-attracting plants and their volatile compounds reveal a potential distinct mechanism of action for actinidine

BMC Biology, 2022
Background It has been known for centuries that cats respond euphorically to Nepeta cataria (catnip). Recently, we have shown that Lonicera tatarica (Tatarian honeysuckle), Actinidia polygama (silver vine), and Valeriana officinalis (valerian) can also ...
Sebastiaan Bol, Adrian Scaffidi, Evelien M. Bunnik, Gavin R. Flematti   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Effects of a Microbial Enzyme Mixture on Macronutrient Hydrolysis in a Static Simulation of Oro-Gastric Digestion That Models Human Digestive Senescence

Foods
Observational studies have shown that human digestive function declines naturally with age. Oral enzyme supplementation is a candidate strategy to enhance macronutrient digestion in older adults.
Sean M. Garvey, Erin N. Madden, Yunyao Qu, Caroline H. Best, Kelly M. Tinker   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source