Results 51 to 60 of about 1,018,174 (316)
Advancing Structure-Based Drug Development: A Rebuild of the IMCA-CAT Beamline at the Advanced Photon Source [PDF]
Structural DynamicsIMCA-CAT is a structural biology beamline located at the Advanced Photon Source (APS) that caters to pharmaceutical companies for drug discovery. During the 2023-2024 APS-U shutdown, IMCA-CAT undertook a comprehensive beamline upgrade - essentially ...
Melissa Carrillo +9 more
doaj +1 more source
Rhinosporidiosis in a Cat [PDF]
Journal of Veterinary Diagnostic Investigation, 2001 A polypoid nasal mass from an adult cat was submitted for routine biopsy examination and was found to contain sporangia and sporangiospores consistent with Rhinosporidium seeberi. Inflammatory infiltrates were moderate and pyogranulomatous to lymphohistiocytic and were associated with hyperplasia of the transitional nasal epithelium.
P G, Moisan, S V, Baker
openaire +2 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Medicina, 2018 Introducción y objetivo: La respuesta inmune en el embarazo varía de acuerdo a la enfermedad reumática presente. Describir los embarazos de mujeres con enfermedades reumáticas en una Clínica de Artritis Temprana. Métodos: Estudio descriptivo.
María A. Moreno-Salamanca +1 more
doaj
Design and ATEX-Aware Kinematic Analysis of a Multi-Body Robot for Gas Pipeline Inspection
IEEE AccessThis paper presents the design and theoretical validation of a multi-body in-pipe inspection robot intended for operation in natural gas pipelines under the ATEX Directive 2014/34/EU.
Franco Rivadeneira +2 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Groups acting on CAT(0) cube complexes
, 1997 We show that groups satisfying Kazhdan's property (T) have no unbounded actions on finite dimensional CAT(0) cube complexes, and deduce that there is a locally CAT(-1) Riemannian manifold which is not homotopy equivalent to any finite dimensional ...
Niblo, Graham, Reeves, Lawrence
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source