Results 51 to 60 of about 1,039,561 (316)
Advancing Structure-Based Drug Development: A Rebuild of the IMCA-CAT Beamline at the Advanced Photon Source [PDF]
Structural DynamicsIMCA-CAT is a structural biology beamline located at the Advanced Photon Source (APS) that caters to pharmaceutical companies for drug discovery. During the 2023-2024 APS-U shutdown, IMCA-CAT undertook a comprehensive beamline upgrade - essentially ...
Melissa Carrillo +9 more
doaj +1 more source
Rhinosporidiosis in a Cat [PDF]
Journal of Veterinary Diagnostic Investigation, 2001 A polypoid nasal mass from an adult cat was submitted for routine biopsy examination and was found to contain sporangia and sporangiospores consistent with Rhinosporidium seeberi. Inflammatory infiltrates were moderate and pyogranulomatous to lymphohistiocytic and were associated with hyperplasia of the transitional nasal epithelium.
P G, Moisan, S V, Baker
openaire +2 more sources
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Groups acting on CAT(0) cube complexes
, 1997 We show that groups satisfying Kazhdan's property (T) have no unbounded actions on finite dimensional CAT(0) cube complexes, and deduce that there is a locally CAT(-1) Riemannian manifold which is not homotopy equivalent to any finite dimensional ...
Niblo, Graham, Reeves, Lawrence
core +1 more source
Medicina, 2018 Introducción y objetivo: La respuesta inmune en el embarazo varía de acuerdo a la enfermedad reumática presente. Describir los embarazos de mujeres con enfermedades reumáticas en una Clínica de Artritis Temprana. Métodos: Estudio descriptivo.
María A. Moreno-Salamanca +1 more
doaj
Design and ATEX-Aware Kinematic Analysis of a Multi-Body Robot for Gas Pipeline Inspection
IEEE AccessThis paper presents the design and theoretical validation of a multi-body in-pipe inspection robot intended for operation in natural gas pipelines under the ATEX Directive 2014/34/EU.
Franco Rivadeneira +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source