Results 71 to 80 of about 657,880 (266)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Analysis of Quantum Machine Learning Methods for Geochemical Pattern Recognition

IEEE Access
Geochemical data analysis presents challenges due to multi-element interactions and non-linear spatial patterns that classical methods struggle to capture.
Brian Keith-Norambuena, Matias Orellana-Hormazabal, Italo L. Montofre-Bacigalupo, Joseline Tapia-Zamora, Angelica Flores-Bustos, Carolina Flores-Bustos, Rodrigo Rojas-Ardiles, Javiera Canales, Maximiliano Araya, Elizabeth J. Lam-Esquenazi   +9 more
doaj   +1 more source

Bereaved Mothers and Masculine Queens: The Political Use of Maternal Grief in 1–2 Kings

Open Theology, 2020
Recent research demonstrates that maternal grief functions paradigmatically to epitomize despair and sorrow in the Hebrew Bible. These literary uses of maternal grief reinforce the stereotype of womanhood, defined by devotion to children and anguish at ...
Quine Cat
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Pancreatitis in Cats

Topics in Companion Animal Medicine, 2012
Pancreatitis was considered a rare disease in the cat until a couple of decades ago when several retrospective studies of severe acute pancreatitis were published. It was apparent that few of the diagnostic tests of value in the dog were helpful in cats.
Armstrong, P. Jane, Williams, David A.
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Being Your Cat: What’s Really Going on in Your Feline’s Mind - By C Haddon and D Mills (2023). Published by Octopus Publishing Group, Carmelite House, London EC4Y 0DZ, UK. 256 pages Paperback (ISBN: 9781788404051). Price £14.99.

Animal Welfare, 2023
Sarah Ellis
doaj   +1 more source

FMMix: A Novel Augmentation Strategy for Enhancing Feature Diversity to Boost Model Generalization for Image Data

IEEE Access
Data augmentation, pivotal for enhancing model performance and generalization, has seen significant advancements with mixed-sample techniques that blend elements from multiple training instances.
Khoa Tho Anh Nguyen, Ngoc Hong Tran, Vinh Quang Dinh   +2 more
doaj   +1 more source

Aldosterone and progesterone-secreting adrenocortical adenocarcinoma in a cat with a concurrent meningioma

Journal of Feline Medicine and Surgery Open Reports, 2016
Case summary A 12-year-old, male neutered domestic shorthair cat was referred for investigation of suspected hyperaldosteronism due to persistent hypokalaemia, hindlimb ataxia, weakness of 1 month’s duration and a left adrenal mass that was detected on ...
Jana Leshinsky, Julia A Beatty, Anne Fawcett, Katja Voss, Mariano Makara, Mark B Krockenberger, Vanessa R Barrs   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source