Results 81 to 90 of about 2,312,470 (291)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Migration and Economic Growth: a 21st Century Perspective [PDF]

While there is extensive literature on the determinants of migration and its microeconomic effects, the New Zealand theoretical or empirical literature specifically examining the effects of migration on economic growth is not as comprehensive.
Cat Moody
core  

Parabolic isometries of CAT(0) spaces and CAT(0) dimensions

, 2003
We study discrete groups from the view point of a dimension gap in connection to CAT(0) geometry. Developing studies by Brady-Crisp and Bridson, we show that there exist finitely presented groups of geometric dimension 2 which do not act properly on any ...
Ballmann, Ballmann, Bridson, Bridson, Brown, Burago, Charney, Chen, Fujiwara, Gromov, Kapovich, Koji Fujiwara, Nagata, Saeko Yamagata, Takashi Shioya, tom Dieck   +15 more
core   +5 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Aldosterone and progesterone-secreting adrenocortical adenocarcinoma in a cat with a concurrent meningioma

Journal of Feline Medicine and Surgery Open Reports, 2016
Case summary A 12-year-old, male neutered domestic shorthair cat was referred for investigation of suspected hyperaldosteronism due to persistent hypokalaemia, hindlimb ataxia, weakness of 1 month’s duration and a left adrenal mass that was detected on ...
Jana Leshinsky, Julia A Beatty, Anne Fawcett, Katja Voss, Mariano Makara, Mark B Krockenberger, Vanessa R Barrs   +6 more
doaj   +1 more source

Two cases of feline pyothorax : medical versus surgical treatment and associated challenges [PDF]

, 2017
Pyothorax is a rare disease in cats. Underlying causes and treatment recommendations vary greatly between cases. In this case series, the management of two challenging cases of feline pyothorax is discussed.
Bosmans, Tim, Daminet, Sylvie, De Rooster, Hilde, Faut, S, Gorris, Falke, Paepe, Dominique, Smets, Pascale, Van der Vekens, Elke   +7 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

FMMix: A Novel Augmentation Strategy for Enhancing Feature Diversity to Boost Model Generalization for Image Data

IEEE Access
Data augmentation, pivotal for enhancing model performance and generalization, has seen significant advancements with mixed-sample techniques that blend elements from multiple training instances.
Khoa Tho Anh Nguyen, Ngoc Hong Tran, Vinh Quang Dinh   +2 more
doaj   +1 more source