Results 81 to 90 of about 1,039,561 (316)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

CAT passenger staircase

, 2008
CAT passenger ...

core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

CAT equipment exhibit

, 2008
CAT equipment ...

core  

nlesc-nano/CAT: CAT 1.1.0

, 2022
What's Changed ENH: Add support for polyatomic core anchors by @BvB93 in https://github.com/nlesc-nano/CAT/pull/259 BLD: Bump the minimum QMFlows version to 0.12.0 by @BvB93 in https://github.com/nlesc-nano/CAT/pull/260 Full Changelog: https://github ...
Jelena Belić, felipe zapata, Bas van Beek   +2 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

CAT aircraft galley

, 2008
CAT aircraft ...

core  

Being Your Cat: What’s Really Going on in Your Feline’s Mind - By C Haddon and D Mills (2023). Published by Octopus Publishing Group, Carmelite House, London EC4Y 0DZ, UK. 256 pages Paperback (ISBN: 9781788404051). Price £14.99.

Animal Welfare, 2023
Sarah Ellis
doaj   +1 more source

FMMix: A Novel Augmentation Strategy for Enhancing Feature Diversity to Boost Model Generalization for Image Data

IEEE Access
Data augmentation, pivotal for enhancing model performance and generalization, has seen significant advancements with mixed-sample techniques that blend elements from multiple training instances.
Khoa Tho Anh Nguyen, Ngoc Hong Tran, Vinh Quang Dinh   +2 more
doaj   +1 more source

Aldosterone and progesterone-secreting adrenocortical adenocarcinoma in a cat with a concurrent meningioma

Journal of Feline Medicine and Surgery Open Reports, 2016
Case summary A 12-year-old, male neutered domestic shorthair cat was referred for investigation of suspected hyperaldosteronism due to persistent hypokalaemia, hindlimb ataxia, weakness of 1 month’s duration and a left adrenal mass that was detected on ...
Jana Leshinsky, Julia A Beatty, Anne Fawcett, Katja Voss, Mariano Makara, Mark B Krockenberger, Vanessa R Barrs   +6 more
doaj   +1 more source