Results 81 to 90 of about 636,485 (333)

Sensitization to cat allergen and its association with respiratory allergies: cross-sectional study

São Paulo Medical Journal, 2017
Cats are a significant source of allergens that contribute towards worsening of allergic diseases. The aim of this study was to investigate the association between sensitization to cat allergens and allergic respiratory diseases.This was an observational
Clóvis Eduardo Santos Galvão, Gustavo Silveira Graudenz, Jorge Kalil, Fábio Fernandes Morato Castro   +3 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Exosomes in Dogs and Cats: An Innovative Approach to Neoplastic and Non-Neoplastic Diseases [PDF]

, 2021
Emanuela Diomaiuto, Valeria Principe, Adriana De Luca, Flaviana Laperuta, Maria Chiara Alterisio, Antonio Di Loria   +5 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Severe muscle fasciculations and tremor in a cat with hypochloraemic metabolic alkalosis secondary to duodenal obstruction

Journal of Feline Medicine and Surgery Open Reports, 2017
Case summary An 18-month-old, female spayed, Australian Mist cat presented with a 24 h history of muscle tremors and inappetence progressing to collapse with generalised muscle fasciculations.
Alison Jukes, Marcus Gunew, Rhett Marshall   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Quality Appraisal of Guidelines on Cancer-Associated Thrombosis Using AGREE II Instrument and Analysis of Current Status of New Oral Anticoagulants

Clinical and Applied Thrombosis/Hemostasis, 2019
Cancer-associated thrombosis (CAT) studies have increased in recent years and the quality of guidelines to guide the clinical practice of CAT prevention and treatment becomes crucial.
Jiuxing Zhang BS, Juan Xu MS, Wenlong Zhang MS, Meiting Jiang MS, Juan Liu BS, Lei Xu MS, Gaofeng Liu PhD, Zhigang Zhao PhD   +7 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A portable device for nucleic acid quantification powered by sunlight, a flame or electricity. [PDF]

, 2018
A decentralized approach to diagnostics can decrease the time to treatment of infectious diseases in resource-limited settings. Yet most modern diagnostic tools require stable electricity and are not portable.
Cesarman, Ethel, Duru, Jens, Erickson, David, Gardner, Andrea, Kopparthy, Varun Lingaiah, Martin, Jeffrey, Maurer, Toby, Semeere, Aggrey, Snodgrass, Ryan   +8 more
core   +1 more source

Evaluation of renal perfusion in hyperthyroid cats before and after radioiodine treatment [PDF]

, 2017
Background: Hyperthyroidism and chronic kidney disease (CKD) are common in elderly cats. Consequently, both diseases often occur concurrently. Furthermore, renal function is affected by thyroid status. Because changes in renal perfusion play an important
Adams, Adams, Becker, Boag, Brown, Daniel, Debruyn, Dong, Dong, Fischer, Gauthier, Graves, Grenier, Haers, Herget-Rosenthal, Hoek, Hoek, Hyvelin, Kay, Ma, Milner, Ohlerth, Paepe, Paepe, Peterson, Riensche, Slater, Stock, Stock, Stock, Tang, Tsuruoka, Vaske, Volckaert, Williams   +34 more
core   +2 more sources