Results 91 to 100 of about 2,862,190 (313)

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Catalpol improved energy metabolism and inflammation through the SIRT5-mediated signaling pathway to ameliorate myocardial injury

Scientific Reports
Background and purpose: Catalpol (CAT) has diverse pharmacological functions, including cellular homeostasis maintenance and anti-inflammatory effects.
Zihan Zheng, YiZhen Liu, Danli Chen, Jianjun Yang, Lingxuan Ren, Zhen Jin, Weirong Wang, Xuyang Liu, Jianyu He, Nanbo Zheng, Rong Lin   +10 more
doaj   +1 more source

The emerging disease occurrence of pet animals in Bangladesh

Journal of Advanced Veterinary and Animal Research, 2016
Objective: The objective of this study was to identify the current status of emerging diseases of pet animals in Bangladesh and to estimate the percentage of disease occurrence in the pet animals.
Umma Habiba, Rafiqul Islam, Mukter Hossain   +2 more
doaj   +1 more source

CAT booking office, Tainan

, 2008
CAT booking office ...

core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Use of micromolecular copper complexes of thiosemicarbazides as an endogenous catalase inducer/activator

One Health & Risk Management
Introduction. Oxidative stress is a major mechanism in the pathogenesis of many diseases, including severe multifactorial ones. Catalase (CAT), along with superoxide dismutase, is one of the first-line antioxidant defense enzymes.
Lilia ANDRONACHE, Valeriana PANTEA, Aurelian GULEA, Olga TAGADIUC, Valerii MATCOVSCHI, Valentin GUDUMAC   +5 more
doaj  

Attitudes, knowledge and behavior of cat owners of importance for the control of zoonotic diseases

Frontiers in Animal Science
AimSince the general public is insufficiently familiar with the concept and mechanisms of transmission of certain infectious agents from cats to humans, the aim of this study was to assess the attitudes, knowledge, and behaviors of cat owners relevant to
Marko Ristić, Aleksandar Višnjić, Aleksandar Višnjić   +2 more
doaj   +1 more source

Loading of CAT aircraft

, 2008
Loading of CAT ...

core  

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Classification of Cat Skin Diseases Using MobileNetV2 Architecture with Transfer Learning

Journal of Applied Informatics and Computing
Skin diseases in cats often present similar visual symptoms across different conditions, making early and accurate diagnosis challenging for pet owners and veterinarians. This study develops a classification model for cat skin diseases: Fungal Infection,
Dian Saputra Aji, Wahid Miftahul Ashari, Dony Ariyus   +2 more
doaj   +1 more source