Results 81 to 90 of about 3,408,163 (311)
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Translation Quality Assessment Tools and Processes in Relation to CAT Tools
Proceedings of the Second Workshop Human-Informed Translation and Interpreting Technology associated with RANLP 2019, 2019 Modern translation QA tools are the latest attempt to overcome the inevitable subjective component of human revisers. This paper analyzes the current situation in the translation industry in respect to those tools and their relationship with CAT tools. The adoption of international standards has set the basic frame that defines “quality”.
openaire +1 more source
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
FEBS Open Bio, EarlyView.Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
Revista TradumàticaBased on survey data, the study explores the consequences of digital transformation for the well-being of Danish certified translators, focusing on the level of technostress related to translators’ adoption of CAT tools, neural machine translation tools
Tina Paulsen Christensen +2 more
doaj +1 more source
CAT-Tools: Komponenten und Konzepte
In den letzten Jahren wurden die Diskussionen zum Thema Sprach- und Übersetzungstechnologie von neuen Entwicklungen wie neuronaler maschineller Überset-zung und generativen KI-Werkzeugen wie Large Language Models (LLMs) dominiert. Aus der professionellen Übersetzung sind aber traditionelle Übersetzungstechnologien wie Computer-Assisted-Translation ...
openaire +2 more sources