Results 121 to 130 of about 190,565 (312)

Methionine catabolism in Saccharomyces cerevisiae.

, 2006
The catabolism of methionine to methionol and methanethiol in Saccharomyces cerevisiae was studied using (13)C NMR spectroscopy, GC-MS, enzyme assays and a number of mutants.
J. Richard Dickinson, Imray, Louise, De Maeyer, Simon, Philippe Perpète, Virginia W. Gitonga, Dickinson, J Richard, Perpète, Philippe, Konstantinos E. Stavropoulos, Lawton, Andrew I, Olivier Duthoit, Gitonga, Virginia W, Stavropoulos, Konstantinos E, Louise Imray, Duthoit, Olivier, Hewlins, Michael J E, Andrew I. Lawton, Michael J. E. Hewlins, Simon De Maeyer   +17 more
core   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Biothermodynamic Analysis of Caenorhabditis elegans: Model of Growth and Metabolism Based on Empirical Formulas, Metabolism Reactions, and Thermodynamic Properties of Living Matter and Metabolism

Biophysica
Caenorhabditis elegans is among the most important model organisms. It has been extensively studied from the perspective of life and biomedical sciences. However, no model of growth and metabolism of C.
Marko E. Popović, Marta Popović, Dong Pei   +2 more
doaj   +1 more source

Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase

, 2010
Human heme oxygenase-1 (HO-1) carries out heme catabolism supported by electrons supplied from the NADPH through NADPH P450 reductase (POR, CPR). Previously we have shown that mutations in human POR cause a rare form of congenital adrenal hyperplasia. In
Primus E. Mullis, Amit V. Pandey, Pandey, Amit V, Flück, Christa E, Christa E. Flück, Mullis, Primus-Eugen   +5 more
core   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

The catabolism of arginine and ornithine in the liver

, 1999
The liver is a key organ for the catabolism of amino acids in mammals. However, the processes for the catabolism of arginine and ornithine in liver have not been studied in great detail.
O'Sullivan, Dan
core  

Epigenetics of cancer-associated muscle catabolism

, 2017
Cancer patients are commonly affected by cachexia, a wasting process involving muscle and fat. Specifically, loss of the muscle compartment has been associated with poor prognosis and suboptimal response to therapy.
Jason Doles, Rachel LO Olson, Martin E Fernandez-Zapico, Aminah Jatoi, Ryan M Carr, Elisa Enriquez-Hesles   +5 more
core   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Glucose catabolism controls ATC reducing potential and ROS levels.

, 2014
A) ATC (U-HTH7) cellular reducing potential is maintained largely through glucose catabolism. B) ATC (U-HTH83) inhibition of glucose catabolism using 2-deoxyglucose (2-DG) increases intra-cellular ROS levels in a dose dependent fashion.
Stephen Y. Lai (515411), Christopher M. Walker (53611), Ramesh Tailor (321659), Laurence E. Court (515410), Ashley Rubinstein (515408), Heath D. Skinner (515409), Jaehyuk Lee (446648), James A. Bankson (384672), Marc S. Ramirez (446649), Yunyun Chen (515407), Vlad C. Sandulache (515406), Michelle D. Williams (363893)   +11 more
core   +1 more source

SERRATE Regulates Floral Meristem Activity by Antagonizing SHOOT MERISTEMLESS and Repressing Cytokinin Signaling

Advanced Science, EarlyView.
Floral meristem (FM) activity is crucial for the initiation of floral organs. In this study, SE represses IPT7 expression and cytokinin signaling via both the miR171c‐5p–KNAT2 and miR164c–CUC1/2–KNAT2 regulatory modules, thereby repressing FM activity. In contrast, STM induces both KNAT2 and IPT7 expression.
Wen Yang, Yiting Wang, Yuxin You, Zhiyue Wu, Dongbao Li, Xin Wang, Yongsheng Chang, Hang Zhao, Tao Zhu, Dijun Chen, Wei Chen, Bo Sun   +11 more
wiley   +1 more source