Results 121 to 130 of about 265,603 (330)

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Regulatory mechanisms underlying coordination of amino acid and glucose catabolism in Escherichia coli

Nature Communications, 2019
How microbes dynamically coordinate uptake and simultaneous utilization of nutrients in complex nutritional ecosystems is still an open question. Here, we develop a constraint-based modeling approach that exploits non-targeted exo-metabolomics data to ...
M. Zampieri, Manuel Hörl, Florian Hotz, Nicola F. Müller, U. Sauer   +4 more
semanticscholar   +1 more source

catabolism

, 2014
Citation: 'catabolism' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.C00870 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis in the aged

Nature, 2017
Catecholamine-induced lipolysis, the first step in the generation of energy substrates by the hydrolysis of triglycerides, declines with age. The defect in the mobilization of free fatty acids in the elderly is accompanied by increased visceral adiposity,
Christina Camell, Jil Sander, O. Spadaro, Aileen H. Lee, K. Nguyen, A. Wing, Emily L. Goldberg, Y. Youm, Chester W. Brown, J. Elsworth, Matthew S. Rodeheffer, J. Schultze, V. Dixit   +12 more
semanticscholar   +1 more source

Selected genes in the sucrose catabolism pathway.

, 2017
(A) Diagram showing the sucrose catabolism pathway with six genes selected during maize improvement. (B) Expression levels of six selected sucrose catabolism genes in tropical and temperate maize lines.
Junjie Fu (1947568), Yongxiang Li (116212), Xiaohong Yang (109367), Hongwei Zhang (28335), Jie Zhang (64655), Jianhua Wang (159545), Jun Zheng (207297), Guoying Wang (159551), Cheng He (250559)   +8 more
core   +1 more source

The Urea–Creatinine Ratio as Marker of Catabolism Is Affected by Continuous Renal Replacement Therapy

Diagnostics
Background: An elevated urea–creatinine ratio (UCR) is used as a surrogate for catabolism and elevated protein metabolism in critically ill patients. This study investigated the effect of continuous renal replacement therapy (CRRT) on UCR.
Andreas Markl-Le Levé, Petra Hillinger, Simon Woyke, Marco Ronzani, Stefan Schmid, Janett Kreutziger, Christopher Rugg   +6 more
doaj   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Interstitial Collagen Catabolism [PDF]

Journal of Biological Chemistry, 2013
Interstitial collagen mechanical and biological properties are altered by proteases that catalyze the hydrolysis of the collagen triple-helical structure. Collagenolysis is critical in development and homeostasis but also contributes to numerous pathologies. Mammalian collagenolytic enzymes include matrix metalloproteinases, cathepsin K, and neutrophil
openaire   +2 more sources

D-xylose catabolism in fusarium oxysporum

, 1983
The initial steps of D-xylose catabolism in Fusarium oxysporum have been studied. The presence of the oxidoreductase pathway for D-xylose catabolism was demonstrated.
Suihko, Maija-Liisa, Suomalainen, I., Enari, Tor-Magnus   +2 more
core   +1 more source