Results 101 to 110 of about 265,603 (330)

Defective Branched-Chain Amino Acid (BCAA) Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-reperfusion Injury

Cell Metabolism, 2017
Summary Elevated levels of branched-chain amino acids (BCAAs) have recently been implicated in the development of cardiovascular and metabolic diseases but the molecular mechanisms are unknown.
Tao Li, Zhen Zhang, Stephen C. Kolwicz, Lauren Abell, Nathan D. Roe, Maengjo Kim, Bo Zhou, Yang Cao, J. Ritterhoff, Hai-Wei Gu, D. Raftery, Hai-Peng Sun, R. Tian   +12 more
semanticscholar   +1 more source

Bioaccessibility and catabolism of phenolic compounds from jaboticaba (Myrciaria trunciflora) fruit peel during in vitro gastrointestinal digestion and colonic fermentation

, 2020
Jaboticaba peel powder (JPP) digestion was investigated for the first time using an in vitro static model of gastrointestinal digestion associated with a colonic fermentation assay with human feces to elucidate the catabolism and bioaccessibility of ...
Andréia Quatrin, Cristine Rampelotto, Roberson Pauletto, L. H. Maurer, S. M. Nichelle, B. Klein, R. F. Rodrigues, M. Maróstica, Bruna de Souza Fonseca, C. R. de Menezes, Renius de Oliveira Mello, E. Rodrigues, V. Bochi, T. Emanuelli   +13 more
semanticscholar   +1 more source

Mitigating disuse‐induced skeletal muscle atrophy in ageing: Resistance exercise as a critical countermeasure

Experimental Physiology
The gradual deterioration of physiological systems with ageing makes it difficult to maintain skeletal muscle mass (sarcopenia), at least partly due to the presence of ‘anabolic resistance’, resulting in muscle loss.
James McKendry, Giulia Coletta, Everson A. Nunes, Changhyun Lim, Stuart M. Phillips   +4 more
doaj   +1 more source

Unveiling the crucial roles of abscisic acid in plant physiology: implications for enhancing stress tolerance and productivity

Frontiers in Plant Science
Abscisic acid (ABA), one of the six major plant hormones, plays an essential and irreplaceable role in numerous physiological and biochemical processes during normal plant growth and in response to abiotic stresses.
Weiliang Mo, Xunan Zheng, Qingchi Shi, Xuelai Zhao, Xiaoyu Chen, Zhenming Yang, Zecheng Zuo   +6 more
doaj   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Histidine catabolism is a major determinant of methotrexate sensitivity

Nature, 2018
The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase1, which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis2. Depletion of tetrahydrofolate causes cell death by suppressing DNA and RNA production3.
N. Kanarek, Heather R. Keys, J. Cantor, Caroline A. Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Elizaveta Freinkman, Lawrence D. Schweitzer, D. Sabatini   +9 more
semanticscholar   +1 more source

Complex Mechanical Loading and Pro‐Inflammatory Cytokines in Intervertebral Disc Degeneration

JOR Spine
Background Intervertebral disc (IVD) degeneration is a major contributor to low back pain, yet its initiating factors remain unclear. While the individual effects of pro‐inflammatory cytokines and mechanical loading on IVDs have been studied, their ...
Katherine B. Crump, Estefano Muñoz‐Moya, Kim deGraaf, Paola Bermudez‐Lekerika, Nicole Schwendener, Wolf‐Dieter Zech, Christine L. Le Maitre, Jérôme Noailly, Benjamin Gantenbein   +8 more
doaj   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

ATGL promotes autophagy/lipophagy via SIRT1 to control hepatic lipid droplet catabolism

Cell Reports, 2017
SUMMARY Hepatic lipid droplet (LD) catabolism is thought to occur via cytosolic lipases such as adipose triglyceride lipase (ATGL) or through autophagy of LDs, a process known as lipophagy.
Aishwarya Sathyanarayan, M. Mashek, Douglas G. Mashek   +2 more
semanticscholar   +1 more source

Short‐Term Dynamic Unloading of Bovine Tail Discs in Culture Partially Mitigates Induced Degeneration After One‐Strike Trigger

JOR Spine
Introduction Intervertebral disc (IVD) degeneration is driven by a vicious circle of interrelated biological and biomechanical factors. Dynamic unloading, defined as dynamic partial decompression, promotes water and metabolite flow, which is essential ...
Astrid Soubrier, Hermann Kasper, Nadja Vonlanthen, Ilse Jonkers, Sibylle Grad   +4 more
doaj   +1 more source