Results 81 to 90 of about 162,502 (263)
Advanced Science, EarlyView.A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil +7 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu +20 more
wiley +1 more source
Fifty years of advances in bile acid synthesis and metabolism
Journal of Lipid Research, 2009 There are two major pathways that mammalian cells use to supply themselves with cholesterol, one involving the synthesis of sterols from acetyl-CoA and the other the metabolism of cholesterol-rich lipoprotein particles via receptor-mediated endocytosis ...
David W. Russell
doaj +1 more source
Advanced Science, EarlyView.Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang +8 more
wiley +1 more source
GelsLittle is known about cartilaginous endplate (CEP) mechanobiology or how it changes in a catabolic microenvironment, partly due to difficulties in conducting mechanotransduction in vitro.
Katherine B. Crump +6 more
doaj +1 more source
Insulin-like Growth Factors (IGFs) and their binding proteins (IGFBPs) as biomarkers of catabolism [PDF]
Journal of Medical Biochemistry, 2007 The life of an organism depends on its capacity to maintain equilibrium Disease induces acute adaptive responses specific to the stimulus and the organism achieves stability through change.
Nedić Olgica +3 more
doaj
Mediators and Patterns of Muscle Loss in Chronic Systemic Inflammation
Frontiers in Physiology, 2018 Besides its primary function in locomotion, skeletal muscle (SKM), which represents up to half of human's weight, also plays a fundamental homeostatic role.
Sandra Pérez-Baos +5 more
doaj +1 more source
Advanced Science, EarlyView.Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl +27 more
wiley +1 more source
Український журнал серцево-судинної хірургіїAim. To analyse the dynamics of the Neuroendocrine Balance Index (NEBI = ln(Cortisol/PRL)) during the perioperative period of coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) in order to evaluate its potential as an integrative ...
Lada O. Sobanska, Volodymyr I. Cherniy
doaj +1 more source
A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat
Advanced Science, EarlyView.An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su +10 more
wiley +1 more source