Results 71 to 80 of about 265,603 (330)

Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth

Signal Transduction and Targeted Therapy, 2020
Pancreatic ductal adenocarcinoma (PDAC) is well-known for inefficient early diagnosis, with most patients diagnosed at advanced stages. Increasing evidence indicates that elevated plasma levels of branched-chain amino acids (BCAAs) are associated with an
Ming-Zhu Lei, Xu Li, Ye Zhang, Jin-Tao Li, Fan Zhang, Yi-Ping Wang, M. Yin, Jia Qu, Qun-Ying Lei   +8 more
semanticscholar   +1 more source

A conserved oxalyl-coenzyme A decarboxylase in oxalate catabolism

Plant Signaling & Behavior, 2022
The ability to biosynthesize oxalic acid can provide beneficial functions to plants; however, uncontrolled or prolonged exposure to this strong organic acid results in multiple physiological problems.
Ninghui Cheng, Vincent Paris, Xiaolan Rao, Xiaoqiang Wang, Paul A. Nakata   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Renal catabolism of 125I-glicentin

, 1986
The renal catabolism of 125I-glicentin has been studied in vivo by the disappearance of this peptide from the plasma of bilaterally nephrectomized, ureteral-ligated, or normal rats and by using tubular microinfusion techniques.
J. M. Lopez-Novoa, J. C. Santos, L. Thim, A. J. Moody, F. J. Garrote, I. Valverde, L. M. Villamediana   +6 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Food intake is inhibited by oral oleoylethanolamide

Journal of Lipid Research, 2004
Oleoylethanolamide (OEA) may be an endogenous regulator of food intake, and intraperitoneal injection of this compound decreases food intake in 24 h-starved rats (Rodriguez de Fonseca, F., M. Navarro, R. Gómez, L. Escuredo, F. Nava, J. Fu, E.
Mie Julin Nielsen, Gitte Petersen, Arne Astrup, Harald S. Hansen   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Ethanolamine enhances adhesion, promotes microcompartment formation, and modulates gene expression in Levilactobacillus brevis ATCC 14869

Gut Microbes
Ethanolamine is an abundant compound in the gastrointestinal tract and a valuable source of carbon and nitrogen for pathogenic bacteria harboring ethanolamine utilization (eut) genes.
Polycronis P. Akouris, Gerrit A. Stuivenberg, John A. Chmiel, Wongsakorn Kiattiburut, Annabel Poon, Gregor Reid, Jeremy P. Burton   +6 more
doaj   +1 more source

Resistance of chylomicron and VLDL remnants to post-heparin lipolysis in ApoE-deficient mice: the role of apoE in lipoprotein lipase-mediated lipolysis in vivo and in vitro

Journal of Lipid Research, 1998
The interaction of lipoprotein lipase (LPL) with triglyceride-rich lipoproteins is governed by a number of factors, such as apolipoprotein (apo) C-II. The role of apoE in lipolysis is controversial.
Eva Zsigmond, Yasu Fuke, Lan Li, Kunihisa Kobayashi, Lawrence Chan   +4 more
doaj   +1 more source

Vitamin D and Its Metabolites Status before and during Chemotherapy in Caucasian Breast Cancer Patients

Metabolites, 2023
Background: The predictive role of vitamin D (VD) in breast cancer (BC) patients’ survival is still being investigated. This paper aims to evaluate the changes in VD metabolites during chemotherapy (CTH) and the predictive role of VD status in Caucasian ...
Małgorzata Kimsa-Furdzik, Anna Bednarek, Grzegorz Hibner, Paulina Czajka-Francuz, Sylwia Cisoń-Jurek, Dobromiła Karawasiecka, Bożena Szymczak, Jerzy Wojnar, Jerzy Chudek, Tomasz Francuz   +9 more
doaj   +1 more source