Results 181 to 190 of about 265,603 (330)

Intestinal fructose catabolism promotes obesity and insulin resistance via ileal lacteal remodeling. [PDF]

Sci Adv
Lopez ML, Kang T, Espeleta AM, Rubtsova VI, Baek J, Songcuan J, Moyer EM, Kim J, Song WS, Jung S, Lai RW, Binuya A, Lee CH, Lantz AR, D'Sa N, Anica A, Tran E, Chun Y, Choi W, Jang KH, Cho S, Kelly ME, Tamburini IJ, Alam YH, Le J, Ramirez CB, Kataru RP, Hong SP, de Aguiar Vallim TQ, Nicholas DA, Xue KS, Lee G, Bae H, Jang C.   +33 more
europepmc   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

hLMR1, a hepatocyte-specific long noncoding RNA that represses amino acid catabolism through pre-mRNA interaction in human liver. [PDF]

PLoS One
Jaso-Vera ME, Takaoka S, Faccioli LAP, Hu Z, Soto-Gutierrez A, Ruan X.   +5 more
europepmc   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Branched-chain amino acid metabolism and macrophage polarization: potential regulatory nodes and therapeutic targets in diabetes-associated metabolic inflammation. [PDF]

Front Cell Infect Microbiol
Yang R, Yang R, Zhang H, Yang Y, Shi Y, Liu J.   +5 more
europepmc   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Salt Stress Accelerates Tyrosine Depletion by <i>Enterococcus lactis</i> KUST2812: Multi-Omics Insights into Metabolic Remodeling. [PDF]

Foods
Gong X, Ma Q, Zhong Y, Liu Z, Chu C, Yi J, Wang T.   +6 more
europepmc   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

Advanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou, Yuanjiang Cui, Chaoqing Ding, Qian Qian, Deyong Ren   +4 more
wiley   +1 more source

Exercise as a modulator of purinergic signaling and inflammation in cancer-associated sarcopenia: a narrative review. [PDF]

Inflamm Res
de Oliveira EM, Dockhorn VMG, de Souza JVG, Franscescon F, de Resende E Silva DT.   +4 more
europepmc   +1 more source

The Rate of Protein Catabolism [PDF]

Biochemical Journal, 1913
E P, Cathcart, H H, Green
openaire   +2 more sources