ABSTRACT Aim To investigate the factors associated with BWL after gastrectomy using data from the phase III trial (JCOG1001). Methods This post hoc analysis included 728 patients from the JCOG1001. The percentage of BWL (%BWL) was defined as the proportion of decrease in body weight immediately before adjuvant chemotherapy initiation compared with that
Takanobu Yamada +16 more
wiley +1 more source
Transcription factor RonA-driven GlcNAc catabolism is essential for growth, cell wall integrity, and pathogenicity in <i>Aspergillus fumigatus</i>. [PDF]
Gong X +6 more
europepmc +1 more source
This study investigates the prognostic utility of a novel volumetric indicator—psoas volume index (PVI)—for assessing sarcopenia in elderly rectal cancer patients. Sarcopenia classified by our proposed PVI cut‐off values was associated with poor nutritional and inflammatory status, and patients with low PVI showed significantly worse long‐term outcomes.
Gen Tsujio +8 more
wiley +1 more source
ATP13A2-Mediated Spermine Export Modulates Lipid Catabolism in the Endolysosomal System of SH-SY5Y Cells. [PDF]
Marcos AL +2 more
europepmc +1 more source
Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review
ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle +26 more
wiley +1 more source
Integrated transcriptomic and metabolomic analyses reveal flavonoid and lipid metabolic reprogramming in <i>Dendrobiumofficinale</i> during <i>Colletotrichum fructicola</i>-induced anthracnose. [PDF]
Yang J +6 more
europepmc +1 more source
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt +9 more
wiley +1 more source
Unexpected Dual Function of Plant YUCCA Enzymes Links Chlorophyll Catabolism to Auxin Homeostasis
YUCCA enzymes are well known to catalyze the main step of auxin biosynthesis in plants. Here, a hitherto undescribed dual function was discovered, revealing that some YUCCAs also act in chlorophyll degradation. In vitro feedback regulation furthermore suggests a link between chlorophyll degradation and hormone homeostasis and a physiological role of ...
Sina Rütschlin +6 more
wiley +2 more sources
Human-Specific Suppression of Hepatic Fatty Acid Catabolism by RNA-Binding Protein HuR. [PDF]
Takaoka S, Jaso-Vera ME, Ruan X.
europepmc +1 more source

