Results 31 to 40 of about 3,552,579 (308)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A survey of the Ichneumonidae (Hymenoptera, Ichneumonoidea) of Kerman province, south-east Iran [PDF]

Journal of Insect Biodiversity and Systematics, 2016
The Ichneumonidae fauna of Kerman province, Iran, was surveyed in April 2013 to June 2014. In total, 35 species belonging to 22 genera and eight subfamilies were collected and identified, of which Cryptus armator Fabricius, 1804; Enizemum schwarzi Diller,
Shahla Mohebban, Hossein Barahoei, Hadji Mohammad Takalloozadeh, Seyed Massoud Madjdzadeh, Matthias Riedel   +4 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

University catalog (Wichita State University)

, 2018
Produced by Lisa Fleetwood, catalog editor, 3/18This catalog is a guide for information only and is not a contract. This catalog becomes effective fall semester 2018 and extends through the summer session 2019. The general university telephone number is
Wichita State University
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

University catalog (Wichita State University)

, 2019
Produced by Lisa Fleetwood, catalog editor, March 2019.This catalog is a guide for information only and is not a contract. This catalog becomes effective fall semester 2019 and extends through the summer session 2020.
Wichita State University
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

The Effect of Next-Generation Catalogs on Catalogers and Cataloging Functions in Academic Libraries [PDF]

Cataloging & Classification Quarterly, 2011
Next-generation catalogs or discovery tools (NGCs) overlay existing bibliographic data and repackage it in displays that differ from the traditional catalog. Many implementations of NGCs have revealed errors, omissions, or inconsistencies in the underlying data that had not been apparent in the traditional catalog.
Susan C. Wynne, Martha J. Hanscom
openaire   +1 more source

University catalog (Wichita State University)

, 2017
Produced by the Office of the Registrar, 4/17.This catalog is a useful tool for students, advisors and university employees needing quick access to the resources, people, policies and procedures that make Wichita State a great place to learn, work, live ...
Wichita State University
core   +1 more source

Addendum and corrections to a synonymic catalog of Neotropical Crabronidae and Sphecidae

Papéis Avulsos de Zoologia, 2005
Errors and omissions found in "A synonymic catalog of the Neotropical Crabronidae and Sphecidae" (Amarante, 2002) are corrected. Substitute names for junior homonyms are proposed, Cerceris cisplatina new name for Cerceris dichroa Brethes, 1909 non Dalla ...
Sérvio Túlio Pires Amarante
doaj   +1 more source