Results 21 to 30 of about 58,437 (310)
The Astrophysical Journal, 1990 Les problemes de reduction systematique des catalogues d'etoiles, afin de creer un systeme positionnel uniforme et un systeme de mouvement propre standard, sont analyses.
L. G. Taff +2 more
openaire +1 more source
The Future of Astrometry in Space
Frontiers in Astronomy and Space Sciences, 2018 This contribution focuses on the importance of astrometry and on its future developments. Over the centuries astrometry has greatly contributed to the advance of the knowledge of the Universe.
Antonella Vallenari
doaj +1 more source
Resource Discovery: Catalogs, Cataloging, and the User [PDF]
Library Trends, 2007 This article considers resource discovery from the viewpoint of visually impaired people. Starting with the tasks of find, identify, select, and obtain, it examines how catalogs can be enhanced to assist visually impaired users. It then looks at the inclusion of specific data within catalog records and how they help the user.
openaire +1 more source
Toward a 21st Century Library Catalog [PDF]
, 2006 Library catalogs have represented stagnant technology for close to twenty years. Moving toward a next-generation catalog, North Carolina State University (NCSU) Libraries purchased Endeca’s Information Access Platform to give its users relevance-ranked ...
Antelman, Kristin +2 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Catalog design, catalog maintenance, catalog governance
Library Collections, Acquisitions, & Technical Services, 2000 The design of library catalogs and the maintenance of their contents equals catalog governance, that is, professional responsibility for the catalog. The design of library catalogs and their contents are an example of the standards that are the hallmark of modern librarianship.
openaire +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source