Results 41 to 50 of about 58,437 (310)
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +12 more sources
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Selection and characterisation of the M dwarf targets in the PLATO Input Catalogue
Context. The aim of the European Space Agency’s PLAnetary Transits and Oscillations of Stars (PLATO) mission is to detect planets orbiting around dwarfs and subgiant stars with spectral type F5 or later, including M dwarfs. The PLATO Input Catalogue (PIC)
Prisinzano L. +35 more
doaj +1 more source
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
A catalog to unite them all: REGALADE, a revised galaxy compilation for the advanced detector era
Context. Many applications in transient science, gravitational wave follow-up, and galaxy population studies require all-sky galaxy catalogs with reliable distances, extents, and stellar masses.
Tranin Hugo +12 more
doaj +1 more source
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez +4 more
wiley +1 more source
Semantic Union Catalogs: The Construction of Union Catalogs Based on BIBFRAME 2.0
[Purpose/significance] With the continuous improvement of bibliographic description models such as BIBFRAME, bibliographic data are facing the transition from MARC to the semantic bibliography. This paper explores the construction model of semantic union
Lin Zefei
doaj +1 more source
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley +1 more source
Evolution of Western Library Catalogs: The Rising Expectations of Users
This paper traces the historical development of library catalogs from primitive catalogs in ancient times to current next generational catalogs, which are summarized into three stages: the agricultural catalog stage, the industrial catalog stage and the ...
Junli Diao
doaj +1 more source

