Results 31 to 40 of about 58,437 (310)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The PLATO field selection process

Astronomy & Astrophysics
The PLanetary Transits and Oscillations of stars (PLATO) mission will begin its four-year nominal mission in early 2027 by monitoring its Long-duration Observation Phase field at South (LOPS2) for at least two years continuously. The primary aim of PLATO
Nascimbeni V., Piotto G., Granata V., Marinoni S., Marrese P. M., Montalto M., Cabrera J., Aerts C., Altavilla G., Belkacem K., Benatti S., Bergemann M., Börner A., Covone G., Deleuil M., Desidera S., Gizon L., Goupil M. J., Günther M., Heras A. M., Malavolta L., Mas-Hesse J. M., Nardiello D., Osborn H. P., Pagano I., Paproth C., Pollacco D., Prisinzano L., Ragazzoni R., Ramsay G., Rauer H., Udry S., Zingales T.   +32 more
doaj   +1 more source

Consolidation of the Gaia catalogue with Chinese Space Station Telescope astrometry

Frontiers in Astronomy and Space Sciences, 2022
The issue of preservation and improvement of the Gaia catalogue throughout the next few decades is addressed. The goal of this study is to evaluate the feasibility of astrometric parameter update, for objects already in the catalogue, by inclusion of new
M. Gai, A. Vecchiato, D. Busonero, A. Riva, R. Cancelliere, M. Lattanzi, Z. Qi   +6 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Deep Bayesian spectral learning for the discovery of hot subdwarf binaries in LAMOST

Astronomy & Astrophysics
Context. Hot subdwarf binaries provide stringent constraints on envelope stripping and binary mass transfer. However, robust identification of these systems in large spectroscopic surveys is hindered by variable data quality and the subtle signatures of ...
Yang Beining, Bu Yude, Zhang Yuhang, Li Qinqin, Lu Guangcheng, Zhang Jiangchuan, Yi Zhenping, Kong Xiaoming, Liu Meng   +8 more
doaj   +1 more source

Russian Virtual Observatory: Data Sources

Open Astronomy, 2016
The purpose of this review is to analyze main directions of creation and functioning of major data sources developed by Russian astronomers or with their participation and to compare them with the worldwide trends in these fields. We discuss astronomical
Malkov O., Dluzhnevskaya O., Bakanas E., Kilpio E., Kniazev A., Kovaleva D., Mironov A., Pakhomov Yu., Ryabchikova T., Rykhlova L., Sachkov M., Sazonov S., Zhukov A.   +12 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Echoes from the dark: Galaxy catalog incompleteness in standard siren cosmology

Astronomy & Astrophysics
Gravitational wave observations can be combined with galaxy catalogs to constrain cosmology and test modified gravity theories using the standard siren method.
Borghi Nicola, Moresco Michele, Tagliazucchi Matteo, Cuomo Giulia   +3 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

EROS light-curve database

Astronomy & Astrophysics
Context. The project called Expérience de Recherche d’Objets Sombres (EROS) carried out photometric surveys of dense stellar fields toward the Magellanic Clouds (LMC and SMC), the Galactic bulge and Galactic spiral arms in the period 1990-2003.
Afonso C., Albert J.-N., Ansari R., Aubourg E., Beaulieu J.-P., Blaineau T., Coutures C., Derue F., Glicenstein J.-F., Goldman B., Hamadache C., Lasserre T., Le Guillou L., Lesquoy E., Magneville C., Mansoux B., Moniez M., Palanque-Delabrouille N., Perdereau O., Rich J., Spiro M., Tisserand P.   +21 more
doaj   +1 more source