Results 71 to 80 of about 209,821 (326)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Machine Learning Etudes in Astrophysics: Selection Functions for Mock Cluster Catalogs

open access: yes, 2015
Making mock simulated catalogs is an important component of astrophysical data analysis. Selection criteria for observed astronomical objects are often too complicated to be derived from first principles.
Alvarez, Marcelo   +2 more
core   +1 more source

Determination of Abundances of Chemical Elements in Open Star Clusters of the Galaxy

open access: yesOpen Astronomy, 2016
Spectroscopic determinations of the relative abundances of chemical elements produced in different nuclear-synthesis processes, [el/Fe], are collected for 90 open star clusters of the Galaxy using data from 109 papers published between 1991 and 2015 ...
Gozha M. L.   +2 more
doaj   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

open access: yesMolecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef   +10 more
wiley   +1 more source

Revised Catalog of GALEX Ultraviolet Sources. I. The All-sky Survey: GUVcat_AIS

open access: yes, 2017
The Galaxy Evolution Explorer (GALEX) imaged the sky in two Ultraviolet (UV) bands, far-UV (FUV) and near-UV (NUV), delivering the first comprehensive sky surveys at these wavelengths.
Bianchi, Luciana   +2 more
core   +1 more source

Astronomical Surveys and Big Data

open access: yesOpen Astronomy, 2016
Recent all-sky and large-area astronomical surveys and their catalogued data over the whole range of electromagnetic spectrum, from γ-rays to radio waves, are reviewed, including such as Fermi-GLAST and INTEGRAL in γ-ray, ROSAT, XMM and Chandra in X-ray,
Mickaelian Areg M.
doaj   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

Cross-Identification Performance from Simulated Detections: GALEX and SDSS

open access: yes, 2009
We investigate the quality of associations of astronomical sources from multi-wavelength observations using simulated detections that are realistic in terms of their astrometric accuracy, small-scale clustering properties and selection functions.
Alexander S. Szalay   +11 more
core   +1 more source

Catalog-to-catalog reductions - Results for the FK, N30, and GC catalogs

open access: yesThe Astrophysical Journal, 1992
It is shown that previous computations of catalog-to-catalog differences, whether by the bin-and-average method or by least-squares adjustment combined with an expansion in an incomplete set of basis functions, have all been performed at inappropriate epoch(s) of place.
B. Bucciarelli   +2 more
openaire   +2 more sources

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

open access: yesAdvanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang   +6 more
wiley   +1 more source

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