Results 161 to 170 of about 2,276,667 (238)

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Inverse Statistics of Active Matter Trajectories to Distinguish Interaction Kernel Anisotropy from Emergent Correlations. [PDF]

Bull Math Biol
Martina-Perez SF.
europepmc   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, EarlyView.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories. [PDF]

Cell
Johnson JAI, Bergman DR, Rocha HL, Zhou DL, Cramer E, Mclean IC, Dance YW, Booth M, Nicholas Z, Lopez-Vidal T, Deshpande A, Heiland R, Bucher E, Shojaeian F, Dunworth M, Forjaz A, Getz M, Godet I, Kurtoglu F, Lyman M, Metzcar J, Mitchell JT, Raddatz A, Solorzano J, Sundus A, Wang Y, DeNardo DG, Ewald AJ, Gilkes DM, Kagohara LT, Kiemen AL, Thompson ED, Wirtz D, Wood LD, Wu PH, Zaidi N, Zheng L, Zimmerman JW, Phillip JM, Jaffee EM, Gray JW, Coussens LM, Chang YH, Heiser LM, Stein-O'Brien GL, Fertig EJ, Macklin P.   +46 more
europepmc   +1 more source

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Institutional Governance for Sustainable Utilisation of Healthcare IoT Technologies: Moving Beyond Technology Acceptance to Conditions of Use. [PDF]

Healthcare (Basel)
Lang Y, Aman A, Keliwon KB, Adznan S, Zhang H.   +4 more
europepmc   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Bioinformatics Approach to mTOR Signaling Pathway-Associated Genes and Cancer Etiopathogenesis. [PDF]

Genes (Basel)
Ozdilli K, Oztan G, Kıvanç D, Oğuz R, Oguz F, Ciftci HS.   +5 more
europepmc   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Blue plaque review series: Mabel Purefoy FitzGerald (1872-1973). [PDF]

Exp Physiol
Tissot van Patot M.
europepmc   +1 more source