Results 171 to 180 of about 2,276,667 (238)

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Anatomy of climate change research in Italian doctoral dissertations using a machine learning approach. [PDF]

Sci Rep
Zinilli A, Tuccari GG, Poggi F, Nuzzolese AG, Mongiovì M, Giammei L, Paolillo R, Longo CF, Ceriani M, Zuppiroli S.   +9 more
europepmc   +1 more source

Data‐Driven Discovery of Unconventional Antiferromagnets

Advanced Science, EarlyView.
A high‐throughput workflow that combines the physics‐informed pre‐screening, high‐throughput exchange calculations, Luttinger‐Tisza analysis and symmetry classification is established for accurate identification of unconventional antiferromagnets from the broad structural database.
Qirui Cui, Chenxu Liu, Anna Delin, Kaiyou Wang   +3 more
wiley   +1 more source

Rethinking bioinformatics in liquid-liquid phase separation: data resources, predictive models, and an event-centric perspective. [PDF]

Brief Bioinform
Yuan ZL, Wang B, Chen YL, Huang HQ, Li BH, Zahoor A, Ren L, Du M, Fang RQ, Ning L.   +9 more
europepmc   +1 more source

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

Advanced Science, EarlyView.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo, Zhenyuan Qian, Lei Wang, Weilang Xu, Yuxin Weng, Kai Jiang, Zaiyuan Ye, Ji Xu, Guangyuan Song   +8 more
wiley   +1 more source

Data Resource Profile: The Lithuanian health data reuse pathway. [PDF]

Int J Epidemiol
Juodakis J, Zubavičiūtė S, Dapkutė A, Greičienė S, Masiliūnas R, Narkevičienė I, Trinkūnas J, Žemaitytė J, Literskė G.   +8 more
europepmc   +1 more source

Chemical‐Biological Fixation for Enhanced Bone Augmentation in Guided Bone Regeneration

Advanced Science, EarlyView.
M2N2ACa is an innovative injectable thermoresponsive barrier membrane adhesive to achieve reliable bone graft fixation. It provides strong wet adhesion and promotes the bio‐stabilization mediated by coagulation through controlled calcium release. This dual‐fixation strategy combines external chemical fixation and internal biological fixation via clot ...
Yu‐zhu Wang, Gao‐peng Dang, Zhi‐ting Li, Zhi‐hong Feng, Que Bai, Jia‐xin Hao, Xiao‐qing Cao, Tao Ye, Jing Li, Franklin R. Tay, Malcolm Xing, Ming Fang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Online Pharmacy Adoption and Consumer Perception: A Systematic Review of Existing Literature. [PDF]

Cureus
Ansari S, Chowhan SS, Sengupta S.
europepmc   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

From violation to stigma: a literature review of athletes' lived experiences following anti-doping sanctions. [PDF]

Front Sports Act Living
Lockett I, Blank C, Patterson L, Westmattelmann D, Lux D, Petróczi A.   +5 more
europepmc   +1 more source