Results 21 to 30 of about 55,692 (274)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Catalogs environment in libraries

open access: yesCybrarians Journal, 2016
The paper discusses cataloguing standards and current applications and future development , Starting of the importance the Collection of the Libraries and Cataloguing, the reality of the Libraries and the shortcomings of the libraries in the face of the
Ahmed Bassiouni
doaj   +1 more source

Fostering population-based cohort data discovery: The Maelstrom Research cataloguing toolkit. [PDF]

open access: yesPLoS ONE, 2018
BACKGROUND:The lack of accessible and structured documentation creates major barriers for investigators interested in understanding, properly interpreting and analyzing cohort data and biological samples.
Julie Bergeron   +4 more
doaj   +1 more source

Our hybrid history and its action points for today [PDF]

open access: yes, 2012
Discusses the hybrid catalogue, highlighting that it has always been with us, and considers what can be learned from previous implementations of new international cataloguing standards in the Anglo-American ...
Welsh, A, Whaite, K
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

SYNERGY OF INTEGRATION OF CATALOGUING AND STANDARDIZATION SYSTEMS IN THE STRUCTURE OF THE EMERCOM OF RUSSIA [PDF]

open access: yesАктуальные вопросы пожарной безопасности
This article examines the potential for the integration of cataloguing and standardization systems in the Ministry of the Russian Federation for Civil Defense, Emergencies and Elimination of Consequences of Natural Disasters (EMERCOM of Russia).
Anatoly A. Shestaev   +3 more
doaj   +1 more source

Standard Cataloguing of Augmented Objects for a Design Museum [PDF]

open access: yesIOP Conference Series: Materials Science and Engineering, 2020
Abstract Demo-ethno-anthropological assets belonging to the cultural heritage are not “autonomous” but represent the nodes of a complex system of relations. Their narration – for the purposes of knowledge and cultural diffusion – cannot transcend this relational dimension that recognises an enormous potential for development in the ...
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy