Results 21 to 30 of about 2,159 (247)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

SYNERGY OF INTEGRATION OF CATALOGUING AND STANDARDIZATION SYSTEMS IN THE STRUCTURE OF THE EMERCOM OF RUSSIA [PDF]

Актуальные вопросы пожарной безопасности
This article examines the potential for the integration of cataloguing and standardization systems in the Ministry of the Russian Federation for Civil Defense, Emergencies and Elimination of Consequences of Natural Disasters (EMERCOM of Russia).
Anatoly A. Shestaev, Alexey A. Novikov, Lilia V. Shcherbatykh, Viktor V. Ermak   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A catalogue of Paschen-line profiles in standard stars [PDF]

Astronomy & Astrophysics, 2012
We have assembled an atlas of line profiles of the Paschen Delta line at 10,049 angstroms for the use of stellar modelling. For a few stars we have substituted the Paschen Gamma line at 10,938 angstroms because the Paschen Delta line blends with other features. Most of the targets are standard stars of spectral types from B to M. A few metal-poor stars
Huang, W., Wallerstein, G., Stone, M.
openaire   +3 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Functional requirements for bibliographic description in digital environments

Transinformação
Nowadays in digital information environments, various types of resources coexist with heterogeneous metadata formats and standards and efforts have been made to achieve interoperability in order to use multiple metadata standards and reuse metadata ...
Fabiano Ferreira de Castro
doaj   +1 more source

Fostering population-based cohort data discovery: The Maelstrom Research cataloguing toolkit. [PDF]

PLoS ONE, 2018
BACKGROUND:The lack of accessible and structured documentation creates major barriers for investigators interested in understanding, properly interpreting and analyzing cohort data and biological samples.
Julie Bergeron, Dany Doiron, Yannick Marcon, Vincent Ferretti, Isabel Fortier   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Uniform processing of library materials – a condition for the exchange and common use of bibliographic records

Knjižnica, 2003
In the Slovenian shared cataloguing system COBISS, uniform processing of library materials is one of the mandatory conditions for a successful functioning of the system. A uniform way of processing assumes use of the same principles, codes and standards,
Tatjana Likar
doaj   +1 more source