Results 121 to 130 of about 464,312 (316)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The effect of base concentration on titanium dioxide nanotubes properties synthesized by hydrothermal method

Journal of Materials Science: Materials in Engineering
The transformation of titania to its nanomaterial form has gained significant interest due to its superior properties that are viable for many applications.
Thembisile Khumalo, Athule Ngqalakwezi, Ntakadzeni Madima, Gary Pattrick, Mpfunzeni Raphulu   +4 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Hydrogen production by dry reforming of methane in a catalytic reactor with La niobate-based hydrogen separation membrane

Chimica Techno Acta
Methane dry reforming is a promising approach for hydrogen production due to the simultaneous utilization of two greenhouse gases, methane and carbon dioxide.
Nikita Eremeev, Dinara Altynbekova, Konstantin Valeev, Tamara Krieger, Arcady Ishchenko, Evgeny Suprun, Vladislav Sadykov, Yulia Bespalko   +7 more
doaj   +1 more source

Chiral Catalysis at the Water/Oil Interface

, 2018
The unique physicochemical properties of water as a solvent have attracted great interest from synthetic chemists for many years, and tremendous research progress on chemical reactions under aqueous conditions has been reported.
Liu, Yan, Li, Can, Guo, Wengang, Liu, Xianghui   +3 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Transformation of Bulk Pd to Pd Cations in Small-Pore CHA Zeolites Facilitated by NO

JACS Au, 2021
Shunsaku Yasumura, Hajime Ide, Taihei Ueda, Yuan Jing, Chong Liu, Kenichi Kon, Takashi Toyao, Zen Maeno, Ken-ichi Shimizu   +8 more
doaj   +1 more source

Environmental catalysis: trends and outlook

, 2002
Environmental catalysis has continuously grown in importance over the last 2 decades not only in terms of the worldwide catalyst market, but also as a driver of advances in the whole area of catalysis.
G. Centi, RUSSO, PAOLA, S. Perathoner, P. Ciambelli   +3 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source