Results 101 to 110 of about 398,278 (315)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Advances in Phillips Polymerisation Catalysis: In-situ Synthesis of Light Linear Alpha Olefins

, 2016
Polyethylene (PE) presents a large class of polymers with an exponentially growing consumption worldwide. Although possessing a relatively simple chemical formula of the repeating CHx units, the chain length, the type and length of the branching, and ...
Sub Inorganic Chemistry and Catalysis, Inorganic Chemistry and Catalysis, Cicmil, D.   +2 more
core  

Perspectives on the Catalytic Processes for the Deep Valorization of Carbohydrates into Fuels and Chemicals

Molecules
The global depletion of fossil resources, combined with accelerating climate change and environmental concerns, is driving intensive research into alternative, sustainable sources of energy and raw materials.
Aigul T. Zamanbekova, Alima K. Zharmagambetova, Assemgul S. Auyezkhanova, Eldar T. Talgatov, Aigul I. Jumekeyeva, Sandugash N. Akhmetova, Alima M. Kenzheyeva   +6 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Catalysis seen in action

, 2015
Synchrotron radiation techniques are widely applied in materials research and heterogeneous catalysis. In homogeneous catalysis, its use so far is rather limited despite its high potential.
Tromp, M.
core   +1 more source

Biofilm-based biocatalysis for β-cyclodextrin production by the surface-display of β-cyclodextrin glycosyltransferase in Bacillus subtilis

Scientific Reports
β-cyclodextrin (β-CD) is an important cyclic oligosaccharide, which is widely applicated in foods, environmental protection, and cosmetics, primarily prepared from enzymatic synthesis in traditional industry.
Dan Wang, Sinan Wang, Wenjun Sun, Tianpeng Chen, Caice Liang, Pengpeng Yang, Qingguo Liu, Chunguang Zhao, Yong Chen   +8 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Shell-Isolated Nanoparticle-Enhanced Raman Spectroscopy for Heterogeneous Catalysis: Verbeterde Raman Spectroscopie door Schil-Geïsoleerde Nanodeeltjes voor Heterogene Katalyse

, 2019
The goals of this PhD thesis are as follows: first, to advance SHINERS towards a more stable and universal characterization technique. Second, to apply SHINERS for the observation and characterization of catalytically relevant surface species during in ...
Sub Inorganic Chemistry and Catalysis, Inorganic Chemistry and Catalysis, Hartman, Thomas   +2 more
core  

Dynamic Combinatorial Chemistry in Chemical Catalysis

, 2013
Despite the progress in the field of dynamic combinatorial chemistry (DCC), dynamic combinatorial catalysis has received considerably less attention. Some first studies, however, have provided proof of principle and demonstrated that DCC-based approaches
Paweł Dydio, Reek, J.N.H., Breuil, P.A.R., Pierre‐Alain R. Breuil, Joost N. H. Reek, Dydio, P.   +5 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source