Results 101 to 110 of about 10,401,391 (311)
Identification of the kinetic mechanism of succinyl-CoA synthetase
Bioscience Reports, 2013 The kinetic mechanism of SCS [succinyl-CoA (coenzyme A) synthetase], which participates in the TCA (tricarboxylic acid) cycle, ketone body metabolism and haem biosynthesis, has not been fully characterized.
Xin Li, Fan Wu, Daniel A. Beard
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Marine DrugsHere, we report on a bifunctional alginate lyase (Vnalg7) expressed in Pichia pastoris, which can degrade natural Undaria pinnatifida into unsaturated guluronic acid di- and trisaccharide without pretreatment.
Hui Wang +5 more
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Catalytic mechanism of the tyrosinase reaction toward the Tyr98 residue in the caddie protein
PLoS Biology, 2018 Tyrosinase (EC 1.14.18.1), a copper-containing monooxygenase, catalyzes the conversion of phenol to the corresponding ortho-quinone. The Streptomyces tyrosinase is generated as a complex with a “caddie” protein that facilitates the transport of two ...
Y. Matoba +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
The Activation and Selectivity of the Legionella RavD Deubiquitinase
Frontiers in Molecular Biosciences, 2021 Eric Schulze-Niemand +3 more
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Philosophical Magazine LettersThe growing demand for renewable energy sources has driven research efforts towards highly efficient electrochemical processes, especially the Hydrogen Evolution Reaction (HER) which is an essential component in renewable hydrogen production. Single Atom
Fares Chabira +4 more
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
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The mechanism of catalytic decomposition [PDF]
Proceedings of the Royal Society of London. Series A, Containing Papers of a Mathematical and Physical Character, 1925 Abstract In recent years a large amount of evidence has accumulated showing that the range of molecular attraction is very small; hence the specific catalytic action of each substance must decrease very fast as the distance of the reacting molecules from the surface increases.
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