Results 91 to 100 of about 240,202 (291)
Capture and Visualization of a Catalytic RNA Enzyme-Product Complex Using Crystal Lattice Trapping and X-Ray Holographic Reconstruction [PDF]
, 2000 James B. Murray +3 more
openalex +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Emergence of catalytic function in prebiotic information-coding polymers
eLifeLife as we know it relies on the interplay between catalytic activity and information processing carried out by biological polymers. Here we present a plausible pathway by which a pool of prebiotic information-coding oligomers could acquire an early ...
Alexei V Tkachenko, Sergei Maslov
doaj +1 more source
Reviving the RNA world: An insight into the appearance of RNA methyltransferases
Frontiers in Genetics, 2016 RNA, the earliest genetic and catalytic molecule, has a relatively delicate and labile chemical structure, when compared to DNA. It is prone to be damaged by alkali, heat, nucleases or stress conditions. One mechanism to protect RNA or DNA from damage is
Ajay Kumar Rana, Serge eAnkri
doaj +1 more source
Characterization of catalytic activity in vitro of the ribozyme targeted to tat-RNA of HIV-I [PDF]
, 1996 L. N. Buryanovsky, А. Д. Швед
openalex +1 more source
FEBS Open Bio, EarlyView.This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc +8 more
wiley +1 more source
The catalytic mechanism of the RNA methyltransferase METTL3 [PDF]
, 2023 Ivan Corbeski +11 more
openalex +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
Insights into functional modulation of catalytic RNA activity [PDF]
, 2008 Anastassios Vourekas +4 more
openalex +1 more source
Advanced Functional Materials, EarlyView.FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu +5 more
wiley +1 more source