Results 191 to 200 of about 240,202 (291)

Mechanistic insights into Lin28-dependent oligo-uridylylation of pre-let-7 by TUT4. [PDF]

Nucleic Acids Res
Han X, Yamashita S, Tomita K.
europepmc   +1 more source

CCR4, a 3′-5′ poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase

, 2002
Junji Chen, Y. C. Chiang, Clyde L. Denis
openalex   +1 more source

Chimeric DNA-RNA hammerhead ribozymes have enhancedin vitrocatalytic efficiency and increased stabilityin vivo [PDF]

, 1992
NERIDA R. TAYLOR, Bruce Kaplan, Piotr Swiderski, Haitang Li, John J. Rossi   +4 more
openalex   +1 more source

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

Emergent Chemical Reactivity and Complexity of RNA Condensates. [PDF]

Angew Chem Int Ed Engl
Hauf S, Nakamura R, Cellini B, Yokobayashi Y, Dindo M.   +4 more
europepmc   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Dual-Site Chemically Engineered MNAzymes for One-Pot Isothermal Detection of MicroRNAs. [PDF]

ACS Omega
Huang Y, Jia C, Tang Y, Zhang J, Zhao R, Zhang J, Chai L.   +6 more
europepmc   +1 more source

Remote Modulation of Single‐Atom Catalyst Boosts High‐Valent Cobalt–Oxo Species Generation for Water Purification and Detoxification

Advanced Science, EarlyView.
This study develops a phosphorus‐doped cobalt single‐atom catalyst that enhances high‐valent cobalt–oxo species generation for water purification. This atomic‐level tuning boosts the catalyst's activity by 3.5 times, enabling efficient pollutant degradation. A continuous‐flow reactor achieves high, long‐term removal efficiency, producing water with low
Wen‐Min Wang, Zheng‐Wei Yang, De‐Xiu Wu, Wen‐Long Wang, Qian‐Yuan Wu   +4 more
wiley   +1 more source

Conformational dynamics of CRISPR-Cas type I-F-HNH inform nickase engineering in a cascade scaffold. [PDF]

Nucleic Acids Res
Fuglsang A, Rout SS, Koutna EB, Sofos N, Gallego AR, Montoya G.   +5 more
europepmc   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source